Gam Arne Nyholm, Thorsen Hanne, Lønnberg Frank
Department of Rheumatology, Bispebjerg Hospital, CopenhagenDenmark Institute of General Practice, University of Copenhagen, CopenhagenDenmark Danish Institute of Clinical Epidemiology, CopenhagenDenmark.
Pain. 1993 Jan;52(1):63-66. doi: 10.1016/0304-3959(93)90114-5.
A meta-analysis was undertaken of low-level laser therapy (LLLT) on musculoskeletal pain. A literature search revealed 23 LLLT trials and of these 17 were controlled trials. Ten were double blind and 7 were insufficiently blinded. Within the studies identified pain was assessed by visual analogue scale or by "some other indices of pain". Nine double-blind trials and 4 controlled trials presented results in a form which allowed pooling of data. In the double-blind trials, the mean difference in pain between LLLT and placebo was 0.3% (S.E.(d) 4.6%, confidence limits -10.3-10.9%). In the insufficiently blinded trials the mean difference in pain was 9.5% (S.E.(d) 4.5%, confidence limits -2.9-21.8%). We conclude that LLLT has no effect on pain in musculoskeletal syndromes.
对低强度激光疗法（LLLT）治疗肌肉骨骼疼痛进行了一项荟萃分析。文献检索发现了23项LLLT试验，其中17项为对照试验。10项为双盲试验，7项的盲法不充分。在已确定的研究中，疼痛通过视觉模拟量表或“其他一些疼痛指标”进行评估。9项双盲试验和4项对照试验以允许数据合并的形式呈现结果。在双盲试验中，LLLT与安慰剂之间的疼痛平均差异为0.3%（标准误（d）4.6%，置信区间-10.3-10.9%）。在盲法不充分的试验中，疼痛平均差异为9.5%（标准误（d）4.5%，置信区间-2.9-21.8%）。我们得出结论，LLLT对肌肉骨骼综合征的疼痛没有影响。
