Medley G F, Guyatt H L, Bundy D A
Wellcome Trust Centre for Research into Parasitic Infections, Imperial College of Science, Technology and Medicine, London.
Parasitology. 1993 Feb;106 ( Pt 2):211-21. doi: 10.1017/s0031182000075016.
There is growing emphasis on the use of community treatment to reduce the level of morbidity caused by helminth infection. The design of chemotherapy programmes, in terms of frequency of treatment and proportion of the community treated, would be assisted by a quantitative framework which enabled the morbidity reduction achieved by different approaches to be compared. The present study describes a model developed for this purpose which embodies two innovative features. First, a quantitative score of morbidity (the proportion of individuals harbouring an intense infection) is used to rate the success of a programme and, second, the distribution of helminths in the host population is generated by a mechanism that allows the distribution to change dynamically as a function of both treatment and reinfection. The model behaviour, using values typical of Ascaris lumbricoides, indicates that the benefit derived from community chemotherapy increases non-linearly with the coverage and efficacy of treatment.
越来越强调使用社区治疗来降低由蠕虫感染引起的发病水平。化疗方案的设计，在治疗频率和接受治疗的社区比例方面，将借助一个定量框架得到帮助，该框架能够比较不同方法实现的发病率降低情况。本研究描述了为此目的开发的一个模型，该模型具有两个创新特征。第一，使用发病率的定量评分（感染严重的个体比例）来评估方案的成功程度；第二，宿主群体中蠕虫的分布由一种机制生成，该机制允许分布根据治疗和再感染动态变化。使用蛔虫典型值的模型行为表明，社区化疗带来的益处随着治疗覆盖率和疗效呈非线性增加。
