Kaaya E, Li S L, Feichtinger H, Stahmer I, Putkonen P, Mandache E, Mgaya E, Biberfeld G, Biberfeld P
Department of Pathology, Karolinska Institute, Stockholm.
Res Virol. 1993 Jan-Feb;144(1):81-92. doi: 10.1016/s0923-2516(06)80016-6.
Thirty-three out of 39 cynomolgus monkeys (Macaca fascicularis) infected with SIVsm (strain SMM-3) developed various pathologies similar to those seen in human AIDS. Lymphadenopathy was frequently seen (72%) and was characterized by hyperplasia followed by involution of follicle/germinal centres due to follicular dendritic cell (FDC) destruction corresponding to the degree of immunodeficiency. Various organs such as the lungs, liver, central nervous system, kidneys, gastrointestinal tract, cardiovascular system and adrenals showed histopathological changes with prominent monocyte/macrophage and multinucleated giant cell formation. Eighteen (54%) monkeys presented with extranodal malignant lymphoma (ML) associated with marked CD4 decrease and destruction of follicular architecture. The high frequency of ML, giant cell disease and lymph node changes seen in the present SIV model provides an attractive system to elucidate the role of FDC and monocytes/macrophages in the pathogenesis of these conditions in common with HIV infection and human AIDS.
39只感染SIVsm（SMM - 3株）的食蟹猴（猕猴）中有33只出现了各种类似于人类艾滋病的病理变化。淋巴结病很常见（72%），其特征是由于滤泡树突状细胞（FDC）破坏导致滤泡/生发中心增生，随后出现萎缩，这与免疫缺陷程度相对应。肺、肝、中枢神经系统、肾、胃肠道、心血管系统和肾上腺等各种器官均出现组织病理学变化，伴有显著的单核细胞/巨噬细胞和多核巨细胞形成。18只（54%）猴子出现结外恶性淋巴瘤（ML），伴有明显的CD4减少和滤泡结构破坏。在当前SIV模型中观察到的ML、巨细胞疾病和淋巴结变化的高频率，为阐明FDC和单核细胞/巨噬细胞在这些与HIV感染和人类艾滋病共有的疾病发病机制中的作用提供了一个有吸引力的系统。
