O'Donovan C, Hawkes J, Bowen R
Department of Psychiatry, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
Acta Psychiatr Scand. 1993 Feb;87(2):92-5. doi: 10.1111/j.1600-0447.1993.tb03336.x.
Lithium has been reported to induce polyuria in up to 35% of patients receiving it. It has been suggested that polyuria may be reduced by using single rather than multiple daily dosing. However, this information is based on non-randomized studies, which used higher serum lithium levels than are currently used. In fact, the incidence of polyuria may be lower at currently used lithium levels, and the benefits of a single daily dose regimen on urine volume at these levels have not been assessed. We conducted a prospective randomized study to test the hypothesis that switching patients from multiple daily dose lithium to single daily dose lithium would significantly lower urine volume. Twenty-four patients previously stabilized on multiple daily dosing were randomly allocated to either single or multiple daily dose lithium. Twenty-four-hour urine volume, serum creatinine, creatinine clearance and serum lithium were measured at study entry and completion. Switching to single daily dose lithium did not significantly reduce the 24-h urine volume.
据报道，在接受锂治疗的患者中，高达35%的人会出现多尿。有人提出，采用每日单次给药而非多次给药可能会减少多尿。然而，这些信息基于非随机研究，所使用的血清锂水平高于目前的使用水平。事实上，在目前使用的锂水平下，多尿的发生率可能较低，且尚未评估每日单次给药方案对这些水平下尿量的影响。我们进行了一项前瞻性随机研究，以检验将患者从每日多次给药的锂治疗改为每日单次给药的锂治疗会显著降低尿量这一假设。24名先前通过每日多次给药病情稳定的患者被随机分配至每日单次给药组或每日多次给药组。在研究开始和结束时测量24小时尿量、血清肌酐、肌酐清除率和血清锂水平。改为每日单次给药的锂治疗并未显著降低24小时尿量。
