Anastassiades O, Iakovou E, Stavridou N, Gogas J, Karameris A
Department of Pathology, General Hospital of Athens, Greece.
Am J Clin Pathol. 1993 Mar;99(3):238-43. doi: 10.1093/ajcp/99.3.238.
A total of 366 consecutive modified radical mastectomy specimens were studied for determination of multicentricity. The authors found that 187 samples (49.1%) were multicentric. Ten specimens contained in situ carcinoma without an infiltrating component; eight of them were multicentric. Multicentricity was correlated with various laboratory and clinical features, including patient age, tumor size, histologic type of breast cancer, tumor grade, presence and values of estrogen and progesterone receptors, the amount of solid tissue in the breast, and the family history. The data were organized in eight independent dimensions, four ordinal and four cardinal. Correlation analysis was applied to a cross tabulation supplemented with other statistical tests. The authors found that the factors related to multicentricity were the age of the patient, the size and the histologic type of the tumor, levels of the progesterone receptors more than 50 fmol/mg of protein, and the amount of solid tissue in the breasts. Tumor grade, estrogen receptors levels, and family history were not related to multicentricity. It was concluded that multicentricity is a frequent property of breast cancer. It is more common in young and perimenopausal women. Multicentricity occurs in small tumors but is, more common in larger ones.
共对366例连续的改良根治性乳房切除术标本进行了多中心性测定研究。作者发现，187个样本（49.1%）为多中心性。10个标本含有原位癌但无浸润成分；其中8个为多中心性。多中心性与多种实验室及临床特征相关，包括患者年龄、肿瘤大小、乳腺癌组织学类型、肿瘤分级、雌激素和孕激素受体的存在及数值、乳房中实性组织的量以及家族史。数据按八个独立维度进行整理，四个为有序维度，四个为基数维度。对交叉表应用相关分析，并辅以其他统计检验。作者发现，与多中心性相关的因素为患者年龄、肿瘤大小和组织学类型、孕激素受体水平超过50 fmol/mg蛋白质以及乳房中实性组织的量。肿瘤分级、雌激素受体水平和家族史与多中心性无关。得出的结论是，多中心性是乳腺癌的常见特征。在年轻和围绝经期女性中更为常见。多中心性在小肿瘤中也会出现，但在大肿瘤中更常见。
