Arch Ophthalmol. 1993 Mar;111(3):339-44.
Cryotherapy for Retinopathy of Prematurity Cooperative Group Reports from the 3- and 12-month follow-up examinations in the Multicenter Cryotherapy for Retinopathy of Prematurity trial indicated a beneficial effect of cryotherapy in the treatment of severe retinopathy of prematurity. This report provides results from the 3 1/2-year follow-up examination on 92% of the 256 survivors from the original cohort of 291 infants in the randomized trial. Functional outcome was evaluated by masked assessment of letter acuity using the HOTV crowded letter test and grating acuity using the Teller Acuity Card procedure. Structural outcome was evaluated by physician's assessment of retinopathy of prematurity residua in the posterior pole. All three outcome measures showed a reduction in unfavorable outcomes in treated vs control eyes: 46.6% vs 57.5% (P < .01) for letter acuity, 52.4% vs 65.6% (P < .001) for grating acuity, and 26.1% vs 45.4% (P < .001) for posterior pole status. These results support the long-term efficacy and safety of cryotherapy in the treatment of severe retinopathy of prematurity.
早产儿视网膜病变多中心冷冻治疗试验中3个月和12个月随访检查的结果表明，冷冻治疗对严重早产儿视网膜病变的治疗有有益效果。本报告提供了对随机试验中291名婴儿原始队列的256名幸存者中92%进行3年半随访检查的结果。通过使用HOTV拥挤字母测试对字母视力进行盲法评估以及使用泰勒视力卡片程序对光栅视力进行评估来评价功能结果。通过医生对后极部早产儿视网膜病变残留情况的评估来评价结构结果。所有这三项结果指标均显示，治疗眼与对照眼的不良结果均有所减少：字母视力方面为46.6%对57.5%（P<.01），光栅视力方面为52.4%对65.6%（P<.001），后极部情况方面为26.1%对45.4%（P<.001）。这些结果支持了冷冻治疗在严重早产儿视网膜病变治疗中的长期疗效和安全性。
