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Studies of the ligand binding to cholera toxin, II. The hydrophilic moiety of sialoglycolipids.

作者信息

Sattler J, Schwarzmann G, Staerk J, Ziegler W, Wiegandt H

出版信息

Hoppe Seylers Z Physiol Chem. 1977 Feb;358(2):159-63. doi: 10.1515/bchm2.1977.358.1.159.

DOI:10.1515/bchm2.1977.358.1.159
PMID:844799
Abstract

The binding between cholera toxin or its B-protein subunit and various ganglioside-related oligosaccharides was studied by equilibrium displacement dialysis. At low concentrations of ligand, the binding of monosialo-gangliotetraitol exceeded that of the parent ganglioside II3NeuAcGgOse4-Cer, the possible cell surface receptor for the toxin. The terminal galactose residue and an intact carboxyl group of the sialic acid moiety of monosialo-gangliotetraose were found to be necessary for strong binding to the toxin.

摘要

相似文献

1
Studies of the ligand binding to cholera toxin, II. The hydrophilic moiety of sialoglycolipids.
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2
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Studies of the ligand binding to cholera toxin, I. The lipophilic moiety of sialoglycolipids.
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Studies of ligand binding to cholera toxin, III. Cooperativity of oligosaccharide binding.霍乱毒素配体结合的研究，III. 寡糖结合的协同性。
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引用本文的文献

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Delineation and comparison of ganglioside-binding epitopes for the toxins of Vibrio cholerae, Escherichia coli, and Clostridium tetani: evidence for overlapping epitopes.霍乱弧菌、大肠杆菌和破伤风梭菌毒素的神经节苷脂结合表位的描绘与比较：重叠表位的证据
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Role of membrane gangliosides in the binding and action of bacterial toxins.
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J Membr Biol. 1982;69(2):85-97. doi: 10.1007/BF01872268.
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J Membr Biol. 1980;54(1):51-60. doi: 10.1007/BF01875376.
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Quantitative description of the binding of GM1 oligosaccharide by cholera enterotoxin.霍乱肠毒素与GM1寡糖结合的定量描述。
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Anti-idiotypic antibodies as probes of protein active sites: application to cholera toxin subunit B.抗独特型抗体作为蛋白质活性位点的探针：在霍乱毒素B亚基中的应用
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