Molin L, Thomsen K, Volden G, Bergqvist-Karlsson A, Hallberg O, Hellbe L
Acta Derm Venereol. 1979;59(1):84-7.
Epipodophyllotoxin (VP-16-213) was administered to 9 patients with mycosis fungoides in various stages, most of them in the advanced tumour stage. In 4 of the patients VP-16 was combined with cyclophosphamide. VP-16 alone or in combination with cyclophosphamide was capable of inducing remission initially in all cases, complete in 2, partial in 3 and improvement to a lesser degree in the remaining 5 patients, but it was unable to maintain the remission. The induced remission has to be upheld by other agents, possibly added to VP-16.
鬼臼乙叉甙（VP-16-213）被用于治疗9例处于不同阶段的蕈样肉芽肿患者，其中大多数处于肿瘤晚期。4例患者中，VP-16与环磷酰胺联合使用。单独使用VP-16或与环磷酰胺联合使用，在所有病例中最初都能够诱导缓解，2例完全缓解，3例部分缓解，其余5例有程度较轻的改善，但无法维持缓解状态。诱导缓解必须通过其他药物来维持，可能需要添加到VP-16中。
