Wadsworth P
Department of Biology, Morrill Science Center, University of Massachusetts, Amherst 01003.
Curr Opin Cell Biol. 1993 Feb;5(1):123-8. doi: 10.1016/s0955-0674(05)80017-1.
New studies on mitosis demonstrate the complexity of interactions that contribute to chromosome motion and spindle assembly. Genetic and immunological approaches reveal the requirement for kinesin-related proteins during cell division in diverse cells. Observations of the dynamic behavior of microtubules demonstrate that their disassembly can produce sufficient force to move chromosomes in vitro, that their poleward movement, or flux, contributes to anaphase motion, and that the direction of anaphase motion can be reversed by induction of kinetochore microtubule elongation.
关于有丝分裂的新研究表明，促成染色体运动和纺锤体组装的相互作用十分复杂。遗传学和免疫学方法揭示了不同细胞在细胞分裂过程中对驱动蛋白相关蛋白的需求。对微管动态行为的观察表明，其解聚能产生足够的力在体外移动染色体，其向极运动或通量有助于后期运动，并且后期运动方向可通过诱导动粒微管延长而逆转。
