Herman I M
Program in Cell, Molecular and Developmental Biology, Tufts University Health Science Schools, Boston, Massachusetts 02111.
Curr Opin Cell Biol. 1993 Feb;5(1):48-55. doi: 10.1016/s0955-0674(05)80007-9.
The actin supergene family encodes a number of structurally related, but perhaps functionally distinct, protein isoforms that regulate contractile potential in muscle tissues and help to control the shape as well as the motility of non-muscle cells. In spite of the documented conservation amongst isoactin genes and their encoded proteins, recent results of biochemical, antibody localization, molecular mutagenesis and isoactin gene replacement studies lend credence to the notion that functional differences amongst muscle and non-muscle actin isoforms exist. Furthermore, the discovery of a new class of actin isoforms, the actin-related proteins, reveals that the actin gene and protein isoform family is more complex than was previously believed.
肌动蛋白超基因家族编码许多结构相关但功能可能不同的蛋白质异构体，这些异构体调节肌肉组织中的收缩潜能，并有助于控制非肌肉细胞的形状和运动性。尽管已证明肌动蛋白异构体基因及其编码蛋白具有保守性，但最近的生化、抗体定位、分子诱变和肌动蛋白异构体基因替代研究结果支持了肌肉和非肌肉肌动蛋白异构体之间存在功能差异这一观点。此外，一类新的肌动蛋白异构体，即肌动蛋白相关蛋白的发现，揭示了肌动蛋白基因和蛋白质异构体家族比以前认为的更为复杂。
