Gold G E, Pauly J M, Glover G H, Moretto J C, Macovski A, Herfkens R J
Department of Radiology, Stanford University, CA 94305.
J Magn Reson Imaging. 1993 Mar-Apr;3(2):399-407. doi: 10.1002/jmri.1880030216.
It is shown that a conventional 1.5-T magnetic resonance (MR) imaging system can help characterize some of the key components of atherosclerotic plaque ex vivo. Fresh human aorta with atheromata was suspended in solutions of agarose and manganese chloride and heated to body temperature. The specimens were imaged with modified Dixon and projection-reconstruction imaging sequences. The specimens were then examined histologically to obtain direct correlation between images, spectra, and histologic characteristics. The results show that vessel wall and plaque components can be identified by means of their MR characteristics and correlated with their histologic appearance. The authors were able to identify normal vessel wall components, such as adventitial lipids and smooth muscle. They were also able to identify and localize plaque components such as fibrous tissue, calcification, lipids, and possible areas of hemorrhage and hemosiderin deposition.
结果表明，传统的1.5-T磁共振（MR）成像系统有助于在体外对动脉粥样硬化斑块的一些关键成分进行特征描述。将带有动脉粥样瘤的新鲜人体主动脉悬浮于琼脂糖和氯化锰溶液中，并加热至体温。采用改良的狄克逊（Dixon）序列和投影重建成像序列对标本进行成像。然后对标本进行组织学检查，以获得图像、光谱和组织学特征之间的直接相关性。结果表明，血管壁和斑块成分可通过其磁共振特征进行识别，并与其组织学外观相关联。作者能够识别正常血管壁成分，如外膜脂质和平滑肌。他们还能够识别并定位斑块成分，如纤维组织、钙化、脂质以及可能的出血和含铁血黄素沉积区域。
