Maertens de Noordhout A, Timsit-Berthier M, Timsit M, Schoenen J
Ann Neurol. 1986 Jan;19(1):78-80. doi: 10.1002/ana.410190115.
Contingent negative variation (CNV), an event-related slow cerebral potential, was analyzed in 79 consecutive headache patients. Compared to normal controls (n = 33), CNV did not differ in tension headache (n = 21) or in combined headaches with a predominant tension component (n = 13). The mean amplitude of CNV was significantly (p less than 0.001) increased in migraine (n = 29) as well as in combined headache with predominant migraine (n = 16). All migraineurs were studied between attacks and without prophylactic treatment. CNV may be a useful diagnostic test in headache. Its increased amplitude in migraine might reflect central catecholaminergic hyperactivity.
对79例连续性头痛患者分析了关联性负变（CNV），这是一种与事件相关的慢脑电位。与正常对照组（n = 33）相比，紧张性头痛患者（n = 21）或主要为紧张性成分的混合性头痛患者（n = 13）的CNV无差异。偏头痛患者（n = 29）以及主要为偏头痛的混合性头痛患者（n = 16）的CNV平均波幅显著增加（p<0.001）。所有偏头痛患者均在发作间期且未接受预防性治疗的情况下接受研究。CNV可能是一种有用的头痛诊断测试。其在偏头痛中波幅增加可能反映中枢儿茶酚胺能亢进。
