San-Blas G, San-Blas F, Serrano L E
Infect Immun. 1977 Feb;15(2):343-6. doi: 10.1128/iai.15.2.343-346.1977.
The yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9 reduced the amount of alpha-1,3-glucan in its cell wall from 45 to 3% when subcultured in vitro for several years. This strain regained its alpha-1,3-glucan up to 25% of the total cell wall when grown in vivo. A mutant strain of P. brasiliensis Pb9, named IVIC Pb140, reported to have 1,3-mannan instead of alpha-glucan in the cell wall, could not be recovered from experimentally infected animals. The existence of some relationship between the presence of alpha-1,3-glucan in the cell wall of the yeastlike form and the pathogenicity of this fungus is suggested in this report.
巴西副球孢子菌IVIC Pb9菌株的酵母样形态在体外传代培养数年时,其细胞壁中α-1,3-葡聚糖的含量从45%降至3%。该菌株在体内生长时,其α-1,3-葡聚糖含量可恢复至占总细胞壁的25%。据报道,巴西副球孢子菌Pb9的一个突变菌株IVIC Pb140,其细胞壁中含有1,3-甘露聚糖而非α-葡聚糖,无法从实验感染的动物中分离出来。本报告提示,酵母样形态细胞壁中α-1,3-葡聚糖的存在与该真菌的致病性之间存在某种关系。