Murphy D M, Stassen L, Carr M E, Gillespie W A, Cafferkey M T, Falkiner F R
J Clin Pathol. 1984 Jun;37(6):673-6. doi: 10.1136/jcp.37.6.673.
The relation between the timing of prophylactic antibiotic administration and the occurrence of bacteraemia during transurethral operations was studied in 112 patients whose urine was infected before operation. Blood cultures taken during operation were positive in 15 (60%) of 25 patients who did not receive appropriate antibiotics, in 13 (21%) of 63 patients who were given appropriate antibiotics less than 24 h before operation, and in none of 24 patients in whom antibiotic "cover" was started more than 24 h before operation. In all cases the bacteraemia was transient. No patient developed septicaemia. The implications of these findings for the optimum timing of antibiotic administration to patients with preoperative bacteriuria are discussed.
对112例术前尿液已感染的患者进行了研究，以探讨预防性使用抗生素的时间与经尿道手术期间菌血症发生之间的关系。在未接受适当抗生素治疗的25例患者中，有15例（60%）手术期间血培养呈阳性；在术前不到24小时给予适当抗生素治疗的63例患者中，有13例（21%）血培养呈阳性；而在术前24小时以上开始给予抗生素“覆盖”的24例患者中，无一例血培养呈阳性。在所有病例中，菌血症均为一过性。无患者发生败血症。讨论了这些发现对术前菌尿症患者抗生素给药最佳时间的意义。
