Maynard J H, Jenkins S M, Moran J, Addy M, Newcombe R G, Wade W G
Department of Periodontology, Dental School, University of Wales College of Medicine, Heath Park, Cardiff, UK.
J Clin Periodontol. 1993 Mar;20(3):207-11. doi: 10.1111/j.1600-051x.1993.tb00345.x.
The effects of 1% chlorhexidine and 1% chlorhexidine/fluoride dentifrices on supragingival plaque flora were investigated in a 6-month home-usage study. 146 subjects were studied from whom plaque around 6 teeth was collected at baseline, 6 weeks and 24 weeks. Total anaerobic counts were reduced at 6 and 24 weeks in both active groups compared to control. No differences were seen in any other bacterial parameters. There was a significant decrease in the susceptibility to chlorhexidine of bacteria recovered from the subjects on the active treatments compared to control but, since the magnitude of effect was less than one dilution, this was not thought to be of any clinical significance.
在一项为期6个月的家庭使用研究中，调查了1%洗必泰牙膏和1%洗必泰/氟化物牙膏对龈上菌斑菌群的影响。研究了146名受试者，在基线、6周和24周时收集了6颗牙齿周围的菌斑。与对照组相比，两个活性组在6周和24周时的总厌氧菌计数均降低。在任何其他细菌参数方面均未观察到差异。与对照组相比，接受活性治疗的受试者所分离出的细菌对洗必泰的敏感性显著降低，但由于效应幅度小于一个稀释度，因此认为这没有任何临床意义。
