Mengel R, Wissing E, Schmitz-Habben A, Florès-de-Jacoby L
Department of Periodontology, School of Dentistry, Philipps University Marburg, Germany.
J Clin Periodontol. 1996 Apr;23(4):372-8. doi: 10.1111/j.1600-051x.1996.tb00560.x.
This comparative clinical 9-month study was designed to examine the efficacy of amine/stannous fluoride (AmF/SnF2) (Meridol) and sodium fluoride (NaF). 150 probands with chronic gingivitis or early signs of periodontitis were divided into 3 randomised groups. Group 1 was given a NaF toothpaste and an NaF mouthrinse, group 2 AmF/SnF2 toothpaste and mouthrinse, and group 3 AmF/SnF2 toothpaste and NaF mouthrinse. The probands were examined at intervals (0, 1, 3 and 9 months) under conditions of a clinical double-blind study. The parameters recorded were the plaque index (PlI), the approximal plaque index (API), the gingival index (GI) and the mod. sulcus bleeding index (SBI). The probing depths (PD) were also measured. The composition of the supragingival plaque was evaluated by dark-field microscopy. A highly significant reduction in all clinical parameters was recorded in all 3 groups in the course of the study. The most pronounced reduction in PlI, API, SBI and PD was recorded in group 2. In the group comparison, however, no significant differences were recorded. Microbiological examination revealed a highly significant increase in cocci and a decrease in rods in all 3 groups. There was also a significant reduction in spirochetes, filaments and fusiforms in groups 2 and 3. In group 1, there was a significant fall only in fusiforms and small spirochetes. Overall, no significant difference in clinical parameters was recorded in the group comparison. However, the use of AmF/SnF2 toothpaste and mouthrinse (group 2) and, to a lesser degree, the combined use of AmF/SnF2 toothpaste and NaF mouthrinse display a favorable microbiological effect. The results from the present double-blind study reveal a reduction in gingival inflammation and supragingival plaque accumulation with a positive change in plaque flora in all groups. The reduction in potentially gingivopathogenic bacteria was slightly higher in the amine/stannous fluoride group.
这项为期9个月的比较性临床研究旨在检验胺/氟化亚锡（AmF/SnF2）（美利道）和氟化钠（NaF）的疗效。150名患有慢性牙龈炎或牙周炎早期症状的受试者被随机分为3组。第1组使用含NaF牙膏和NaF漱口水，第2组使用含AmF/SnF2牙膏和漱口水，第3组使用含AmF/SnF2牙膏和NaF漱口水。在临床双盲研究条件下，定期（0、1、3和9个月）对受试者进行检查。记录的参数有菌斑指数（PlI）、邻面菌斑指数（API）、牙龈指数（GI）和改良龈沟出血指数（SBI）。还测量了探诊深度（PD）。通过暗视野显微镜评估龈上菌斑的组成。在研究过程中，所有3组的所有临床参数均有极显著降低。第2组的PlI、API、SBI和PD降低最为明显。然而，在组间比较中，未记录到显著差异。微生物学检查显示，所有3组的球菌数量均有极显著增加，杆菌数量减少。第2组和第3组的螺旋体、丝状菌和梭形菌也有显著减少。在第1组中，仅梭形菌和小螺旋体数量有显著下降。总体而言，组间比较未记录到临床参数的显著差异。然而，使用含AmF/SnF2牙膏和漱口水（第2组）以及在较小程度上使用含AmF/SnF2牙膏和NaF漱口水的联合使用显示出良好的微生物学效果。本双盲研究结果显示，所有组的牙龈炎症和龈上菌斑积聚均有所减少，菌斑菌群有积极变化。胺/氟化亚锡组中潜在致牙龈病细菌的减少略高。
