Binney A, Addy M, McKeown S, Everatt L
Department of Oral and Dental Science, University of Bristol, England.
J Clin Periodontol. 1995 Nov;22(11):830-4. doi: 10.1111/j.1600-051x.1995.tb01780.x.
Many compounds could be added to toothpaste to assist plaque inhibition, but ionic interactions can cause formulation difficulties. Moreover, the actual chemical action of a plaque inhibitory agent added to a toothpaste is difficult to assess when the product is used in the conventional manner, i.e., in addition to toothbrushing. The non-ionic antimicrobial triclosan has been incorporated in toothpastes and shown to have variable plaque inhibitory activity both alone and in conjunction with certain polymers or metal ions. Little is known of the efficacy of triclosan toothpastes compared to conventional fluoride toothpastes. The aim of this study was to compare a commercially available toothpaste containing 0.3% triclosan/co-polymer with a sodium fluoride toothpaste for chemical plaque inhibitory effects over a 4-day period. The study was designed to stratify the relative efficacy plaque inhibitory action of the products, comparisons were made with a positive control, chlorhexidine rinse and a negative control, saline. The study design was a randomised single blind crossover design balanced for first-order carryover. A total of 18 healthy, dentate volunteers participated in the study. On day 1 of each period the volunteers suspended toothcleaning and rinsed 2 x daily with the allocated mouthrinse or toothpaste slurry. On day 5, the plaque on the teeth was disclosed and scored by index and area. Increasing plaque scores were in the order chlorhexidine, triclosan toothpaste, fluoride toothpaste, and saline. Chlorhexidine was significantly more effective than all the other agents tested, and both toothpaste preparations were significantly better than the saline rinse. There was no significant difference between the two toothpaste rinses. Consistent with other studies the triclosan toothpaste offers only moderate plaque inhibitory properties when compared to a conventional toothpaste.
许多化合物可添加到牙膏中以辅助抑制牙菌斑，但离子相互作用可能会导致配方困难。此外，当以传统方式使用牙膏（即除刷牙外）时，添加到牙膏中的牙菌斑抑制剂的实际化学作用难以评估。非离子抗菌剂三氯生已被纳入牙膏中，并且已证明其单独使用以及与某些聚合物或金属离子联合使用时具有可变的牙菌斑抑制活性。与传统的含氟牙膏相比，人们对三氯生牙膏的功效了解甚少。本研究的目的是比较一种含有0.3%三氯生/共聚物的市售牙膏与一种含氟牙膏在4天内对化学性牙菌斑的抑制作用。该研究旨在对产品的相对功效牙菌斑抑制作用进行分层，与阳性对照氯己定漱口水和阴性对照生理盐水进行比较。研究设计为随机单盲交叉设计，并对一级残留进行了平衡。共有18名健康的有牙志愿者参与了该研究。在每个阶段的第1天，志愿者停止刷牙，并每天用分配的漱口水或牙膏糊剂漱口2次。在第5天，对牙齿上的牙菌斑进行染色并按指数和面积评分。牙菌斑评分增加的顺序为氯己定、三氯生牙膏、含氟牙膏和生理盐水。氯己定比所有其他测试剂都显著更有效，并且两种牙膏制剂都明显优于生理盐水冲洗。两种牙膏漱口水之间没有显著差异。与其他研究一致，与传统牙膏相比，三氯生牙膏仅具有中等的牙菌斑抑制性能。
