Menza M A, Golbe L I, Cody R A, Forman N E
Department of Psychiatry, UMDNJ, Robert Wood Johnson University Medical School, New Brunswick 08903-0019.
Neurology. 1993 Mar;43(3 Pt 1):505-8. doi: 10.1212/wnl.43.3_part_1.505.
Studies suggest that Parkinson's disease (PD) is associated with a particular group of personality characteristics. With relative uniformity, PD patients are described as industrious, rigidly moral, stoic, serious, and nonimpulsive. In this controlled study, we used a recently developed personality questionnaire, Cloningers's Tridimensional Personality Questionnaire, to test the hypothesis that these personality traits are behavioural manifestations of damaged dopaminergic pleasure and reward systems. We found significantly less (p < 0.01) of a group of traits called "novelty seeking" in PD patients compared with matched medical controls. Patients with low novelty seeking are described as being reflective, rigid, stoic, slow-tempered, frugal, orderly, and persistent, characteristics similar to those in the clinical description of PD patients. We review evidence supporting the claim that novelty seeking is dopamine-dependent, and suggest that damage to the mesolimbic dopaminergic system causes the described personality profile of PD patients.
研究表明，帕金森病（PD）与特定的一组人格特征相关。帕金森病患者相对一致地被描述为勤奋、道德刻板、坚忍、严肃且不冲动。在这项对照研究中，我们使用了最近开发的一份人格问卷，即克隆宁格的三维人格问卷，来检验这样一个假设：这些人格特质是受损的多巴胺能愉悦和奖赏系统的行为表现。与相匹配的医学对照组相比，我们发现帕金森病患者中一组被称为“寻求新奇”的特质明显更少（p < 0.01）。寻求新奇程度低的患者被描述为善于思考、刻板、坚忍、脾气慢、节俭、有条理且有毅力，这些特征与帕金森病患者的临床描述相似。我们回顾了支持寻求新奇依赖多巴胺这一说法的证据，并表明中脑边缘多巴胺能系统的损伤导致了帕金森病患者所描述的人格特征。
