Jacobs H, Heberlein I, Vieregge A, Vieregge P
Department of Neurology, Medical University of Lübeck, Germany.
Acta Neurol Scand. 2001 Feb;103(2):82-7. doi: 10.1034/j.1600-0404.2001.103002082.x.
It has been hypothesized that the dopaminergic deficit of older patients with Parkinson's disease (PD) is associated with a reduction in the dopamine-dependent personality trait "novelty seeking". It is unknown whether this may also be found in younger patients with PD whose dopaminergic deficit is considered to be purely motor.
We interviewed 122 patients below 51 years of age and 122 age- and sex-matched healthy controls with regard to clinical and sociodemographic data. Both groups had to fill out the Tridimensional Personality Questionnaire (TPQ) of Cloninger. Neuropsychological testing of formal intelligence and depression was also applied.
"Novelty seeking" was not different between both groups. Patients were more often depressed than controls, explaining their difference in "harm avoidance" on the TPQ. "Persistence", a sub-scale of the third TPQ dimension "reward dependence", was significantly higher in patients. Neither sex, nor age, nor educational status were correlated with one of the three personality traits.
The higher rate of depression explains our finding of more "harm avoidance" among young PD patients. According to a literature review the choice and performance of controls is crucial whether personality traits in PD patients may be assessed as abnormal.
有假设认为，老年帕金森病（PD）患者的多巴胺能缺陷与依赖多巴胺的人格特质“新奇寻求”的降低有关。尚不清楚在多巴胺能缺陷被认为纯粹是运动性的年轻PD患者中是否也会出现这种情况。
我们就临床和社会人口学数据对122名51岁以下的患者以及122名年龄和性别匹配的健康对照者进行了访谈。两组都必须填写克隆宁格的三维人格问卷（TPQ）。还进行了形式智力和抑郁的神经心理学测试。
两组之间“新奇寻求”没有差异。患者比对照者更常出现抑郁，这解释了他们在TPQ上“回避伤害”的差异。TPQ第三个维度“奖赏依赖”的一个子量表“坚持性”在患者中显著更高。性别、年龄和教育程度均与这三种人格特质中的任何一种无关。
较高的抑郁发生率解释了我们在年轻PD患者中发现更多“回避伤害”的现象。根据文献综述，对照者的选择和表现对于是否可以将PD患者的人格特质评估为异常至关重要。
