Takeuchi Hikaru, Kawashima Ryuta
Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Genes (Basel). 2025 Mar 28;16(4):384. doi: 10.3390/genes16040384.
BACKGROUND/OBJECTIVES: Multiple independent studies indicate an association between the occupations of medical doctors and dentists and the risk of Parkinson's disease (PD). This study tried to evaluate the associations between a polygenic risk score (PRS) for Parkinson's disease (PD) and medical career (medical doctor/dentist).
This population-based cross-sectional study used data from the UK Biobank. A total of 92,566 and 166,531 men and women aged 38-73 years, recruited between 2006 and 2010, were included in the analyses of job history and current job, respectively (separate samples). Odds risks for the jobs of medical doctors and dentists were estimated using logistic regression. A PRS of polymorphisms previously shown to predict PD best was constructed and associated with the job history of medical doctors/dentists in the first analysis and with current medical doctor/dentist jobs in the second analysis after regressing out confounding variables.
A high PD PRS was associated with employment as a medical doctor or dentist for both the 92,566 individuals with job history data, with an increase of 1 standardized deviation ( = 0.006), and current employment as medical doctors/dentists among the 166,531 individuals without job history data but with current job data. Furthermore, a higher PD PRS was associated with higher education in both samples.
These results suggest that PD has shared genetic routes with a propensity for higher education and becoming medical doctors/dentists.
背景/目的：多项独立研究表明，医生和牙医的职业与帕金森病（PD）风险之间存在关联。本研究试图评估帕金森病（PD）的多基因风险评分（PRS）与医学职业（医生/牙医）之间的关联。
这项基于人群的横断面研究使用了英国生物银行的数据。分别纳入了2006年至2010年间招募的92566名38至73岁男性和166531名38至73岁女性，分别用于工作史和当前工作的分析（独立样本）。使用逻辑回归估计医生和牙医工作的优势风险。构建了一个先前显示能最佳预测PD的多态性PRS，并在第一次分析中与医生/牙医的工作史相关联，在第二次分析中，在剔除混杂变量后，与当前的医生/牙医工作相关联。
对于有工作史数据的92566名个体，高PD PRS与作为医生或牙医的就业相关，增加了1个标准差（=0.006）；对于没有工作史数据但有当前工作数据的166531名个体，高PD PRS与当前作为医生/牙医的就业相关。此外，在两个样本中，较高的PD PRS都与较高的教育程度相关。
这些结果表明，PD与接受高等教育以及成为医生/牙医的倾向有共同的遗传途径。
