Sharma K R, Mynhier M A, Miller R G
Department of Neuromuscular Research, California Pacific Medical Center, San Francisco 94118.
Neurology. 1993 Mar;43(3 Pt 1):527-32. doi: 10.1212/wnl.43.3_part_1.527.
We investigated the effect of cyclosporine (CsA) on force generation in 15 boys with Duchenne muscular dystrophy (DMD) by obtaining monthly measures of tetanic force and maximum voluntary contraction (MVC) of both anterior tibial muscles. During 4 months of a natural history phase, both tetanic force and MVC declined significantly. During 8 weeks of CsA treatment (5 mg/kg/day), significantly increased tetanic force (25.8 +/- 6.6%) and MVC (13.6 +/- 4.0%) occurred within 2 weeks. The maximum mean increase during treatment was 35.2 +/- 5.9% (tetanic force) and 19.0 +/- 4.6% (MVC). Side effects from CsA, gastrointestinal and flu-like symptoms, were transient and self-limiting. Thus, as previously reported with prednisone, CsA increases muscular force generation in the anterior tibial muscles of DMD patients.
我们通过每月测量15名杜氏肌营养不良症（DMD）男孩双侧胫骨前肌的强直收缩力和最大自主收缩（MVC），研究了环孢素（CsA）对其肌力产生的影响。在4个月的自然病程阶段，强直收缩力和MVC均显著下降。在CsA治疗8周（5mg/kg/天）期间，2周内强直收缩力（25.8±6.6%）和MVC（13.6±4.0%）显著增加。治疗期间最大平均增幅为35.2±5.9%（强直收缩力）和19.0±4.6%（MVC）。CsA的副作用，如胃肠道和流感样症状，是短暂的且可自行缓解。因此，正如先前使用泼尼松的报道一样，CsA可增加DMD患者胫骨前肌的肌力产生。
