用于光动力疗法的新型酞菁光敏剂。
New phthalocyanine photosensitizers for photodynamic therapy.
作者信息
Oleinick N L, Antunez A R, Clay M E, Rihter B D, Kenney M E
机构信息
Department of Radiology, Case Western Reserve University, Cleveland, OH 44106.
出版信息
Photochem Photobiol. 1993 Feb;57(2):242-7. doi: 10.1111/j.1751-1097.1993.tb02282.x.
Six new aluminum and silicon phthalocyanines have been synthesized and their photocytotoxicity toward V79 cells has been studied. The compounds that have been prepared are: A1PcOSi(CH3)2(CH2)3N(CH3)2, I; A1Pc-OSi(CH3)2(CH2)3N(CH3)3+I-, II; CH3SiPcOSi(CH3)2(CH2)3N(CH3)2, III; HOSiPcOSi(CH3)2(CH2)3N(CH3)2, IV; HOSiPcOSi(CH3)2(CH2)3N(CH3)3+I-, V; and SiPc[OSi(CH3)2(CH2)3N(CH3)3+I-]2, VI. Relative growth delay values for compounds I-VI and relative cytotoxicity values for compounds I, II, IV, V and VI have been determined. Compounds I and II have been shown to be comparable in photocytotoxicity to what is presumed to be A1PcOH.xH2O, and compound IV has been shown to have greater activity. The classes of compounds to which these six compounds belong appear to have potential for photodynamic therapy.
已合成了六种新型铝和硅酞菁，并研究了它们对V79细胞的光细胞毒性。所制备的化合物如下：A1PcOSi(CH3)2(CH2)3N(CH3)2，I；A1Pc-OSi(CH3)2(CH2)3N(CH3)3+I-，II；CH3SiPcOSi(CH3)2(CH2)3N(CH3)2，III；HOSiPcOSi(CH3)2(CH2)3N(CH3)2，IV；HOSiPcOSi(CH3)2(CH2)3N(CH3)3+I-，V；以及SiPc[OSi(CH3)2(CH2)3N(CH3)3+I-]2，VI。已测定了化合物I-VI的相对生长延迟值以及化合物I、II、IV、V和VI的相对细胞毒性值。已表明化合物I和II的光细胞毒性与推测的A1PcOH.xH2O相当，并且化合物IV已显示出具有更高的活性。这六种化合物所属的化合物类别似乎具有光动力疗法的潜力。
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