Gribbin M A, Weeks J L, Howe G R
National Cancer Institute of Canada Epidemiology Unit, University of Toronto, Ontario.
Radiat Res. 1993 Mar;133(3):375-80.
The mortality experience between 1956 and 1985 of 8977 males employed by Atomic Energy of Canada Limited is reported. A total of 4260 men, 47% of the cohort, were exposed to low doses of external ionizing radiation at low dose rates, with a mean cumulative equivalent dose of 52.1 mSv. For cancers as a whole the excess relative risk, based on 227 deaths, was 0.36% per 10 mSv (90% confidence bounds -0.46, 2.45). This is quite comparable to the corresponding estimate based on the atomic bomb survivors study. There was a positive association between radiation dose and death from leukemia (excluding chronic lymphatic leukemia) P = 0.058. However, this was based on only four deaths and hence cannot sensibly be compared to estimates based on high-dose studies. The present results suggest that, for cancer as a whole, risk estimates based on high-dose studies are unlikely to underestimate risks substantially for low-dose and low-dose-rate exposures.
报告了1956年至1985年期间受雇于加拿大原子能有限公司的8977名男性的死亡情况。该队列中有4260名男性（占队列的47%）在低剂量率下受到低剂量的外照射，平均累积当量剂量为52.1毫希沃特。对于所有癌症而言，基于227例死亡病例，每10毫希沃特的超额相对风险为0.36%（90%置信区间为-0.46，2.45）。这与基于原子弹幸存者研究的相应估计值相当。辐射剂量与白血病（不包括慢性淋巴细胞白血病）死亡之间存在正相关，P = 0.058。然而，这仅基于4例死亡病例，因此无法合理地与基于高剂量研究的估计值进行比较。目前的结果表明，对于所有癌症而言，基于高剂量研究的风险估计值不太可能大幅低估低剂量和低剂量率照射的风险。
