Brown G C, Lockshin M D, Salvati E A, Bullough P G
J Bone Joint Surg Am. 1977 Mar;59(2):164-8.
We explored the possibility that wear products of cobalt-chromium alloy might lead to sensitivity to metal wear products and in turn to loosening of a component of the prosthesis after total joint replacement. Twenty patients with sterile, loose McKee-Farrar hip replacements had patch tests for sensitivity to cobalt, nickel, and chromium. All tests were negative in all patients. The histological findings from surrounding tissues in seventeen patients who had reoperation showed no signs of delayed hypersensitivity. In five patients, lymphokine assays for migration inhibition factor and blastogenic factor were done. Only one assay was positive. Our findings do not support the suggestion that hypersensitivity to metal is a cause of component loosening after McKee-Farrar total hip replacement.
我们探讨了钴铬合金磨损产物可能导致对金属磨损产物敏感，进而导致全关节置换后假体部件松动的可能性。20例无菌性、McKee-Farrar型髋关节置换松动的患者接受了对钴、镍和铬敏感性的斑贴试验。所有患者的所有检测结果均为阴性。17例接受再次手术患者周围组织的组织学检查结果未显示迟发型超敏反应的迹象。对5例患者进行了迁移抑制因子和母细胞生成因子的淋巴因子检测。只有一项检测呈阳性。我们的研究结果不支持金属超敏反应是McKee-Farrar全髋关节置换后部件松动原因的观点。
