Pham Martin H, Mehta Vivek A, Tuchman Alexander, Hsieh Patrick C
Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Biomed Res Int. 2015;2015:719123. doi: 10.1155/2015/719123. Epub 2015 Oct 7.
Current cervical total disc replacement (TDR) designs incorporate a variety of different biomaterials including polyethylene, stainless steel, titanium (Ti), and cobalt-chrome (CoCr). These materials are most important in their utilization as bearing surfaces which allow for articular motion at the disc space. Long-term biological effects of implanted materials include wear debris, host inflammatory immune reactions, and osteolysis resulting in implant failure. We review here the most common materials used in cervical TDR prosthetic devices, examine their bearing surfaces, describe the construction of the seven current cervical TDR devices that are approved for use in the United States, and discuss known adverse biological effects associated with long-term implantation of these materials. It is important to appreciate and understand the variety of biomaterials available in the design and construction of these prosthetics and the considerations which guide their implementation.
当前的颈椎全椎间盘置换（TDR）设计采用了多种不同的生物材料，包括聚乙烯、不锈钢、钛（Ti）和钴铬合金（CoCr）。这些材料在用作承载表面时最为重要，它们允许椎间盘间隙进行关节运动。植入材料的长期生物学效应包括磨损碎屑、宿主炎症免疫反应以及导致植入失败的骨溶解。我们在此回顾颈椎TDR假体装置中使用的最常见材料，检查它们的承载表面，描述目前在美国被批准使用的七种颈椎TDR装置的构造，并讨论与这些材料长期植入相关的已知不良生物学效应。认识和理解这些假体设计和构造中可用的各种生物材料以及指导其应用的考虑因素非常重要。
