Van Reeth K, Vercruysse J
Faculty of Veterinary Medicine, Department of Parasitology, Gent, Belgium.
Avian Dis. 1993 Jan-Mar;37(1):218-21.
The efficacy of toltrazuril against heavy experimental Eimeria labbeana and E. columbarum infections in racing pigeons was investigated. Pigeons were treated with toltrazuril at a dose of 20 mg/kg body weight before, during, and after the pre-patent period. In pigeons treated during pre-patency (1-5 days postinoculation [PI]), a 99.9% reduction in oocyst output was observed at day 7 PI. Treatment during patency (6-7 days PI) resulted in an interruption of oocyst shedding within 3 to 4 days. Pigeons treated with toltrazuril up to 14 days before the experimental infection showed on average a reduction of more than 97% in the number of oocysts in individual fecal samples. Finally, at reinfection, the immune response of pigeons previously treated during pre-patency was not altered compared with the response of infected unmedicated controls.
研究了托曲珠利对赛鸽严重实验性感染拉氏艾美耳球虫和鸽艾美耳球虫的疗效。在潜隐期之前、期间和之后，给鸽子按20 mg/kg体重的剂量使用托曲珠利进行治疗。在潜隐期（接种后1 - 5天）接受治疗的鸽子，在接种后第7天观察到卵囊排出量减少了99.9%。在发病期（接种后6 - 7天）进行治疗导致在3至4天内卵囊排出中断。在实验性感染前长达14天用托曲珠利治疗的鸽子，单个粪便样本中的卵囊数量平均减少了97%以上。最后，在再次感染时，与未用药的感染对照相比，先前在潜隐期接受治疗的鸽子的免疫反应没有改变。
