与其他急性肝损伤病因相比，对乙酰氨基酚过量导致肾损伤的发生率。
Frequency of renal impairment in paracetamol overdose compared with other causes of acute liver damage.
作者信息
Wilkinson S P, Moodie H, Arroyo V A, Williams R
出版信息
J Clin Pathol. 1977 Feb;30(2):141-3. doi: 10.1136/jcp.30.2.141.
Abstract
In an analysis of 160 patients with fulminant hepatic failure, the frequency of renal failure in the patiens who had taken an overdose of paracetamol was not significantly higher than in those with hepatic failure due to other causes. The same was found in another group of patients with less severe hepatic damage. In both the latter group and the patients with fulminant hepatic failure, the development of renal failure was closely related to the occurrence of endotoxaemia as detected by the Limulus lysate assay. These findings do not support the concept that an overdose of paracetamol has a specific nephrotoxic effect.
摘要
在一项对160例暴发性肝衰竭患者的分析中，服用过量扑热息痛的患者肾衰竭发生率并不显著高于因其他原因导致肝衰竭的患者。在另一组肝损伤较轻的患者中也发现了同样的情况。在后一组患者和暴发性肝衰竭患者中，肾衰竭的发生与鲎试剂检测所发现的内毒素血症的发生密切相关。这些发现并不支持过量服用扑热息痛具有特定肾毒性作用这一观点。
相似文献
1
Frequency of renal impairment in paracetamol overdose compared with other causes of acute liver damage.与其他急性肝损伤病因相比，对乙酰氨基酚过量导致肾损伤的发生率。
J Clin Pathol. 1977 Feb;30(2):141-3. doi: 10.1136/jcp.30.2.141.
2
Paracetamol poisoning and the kidney.
J Clin Pharm Ther. 1993 Feb;18(1):5-8. doi: 10.1111/j.1365-2710.1993.tb00560.x.
3
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.对乙酰氨基酚引起的急性肾衰竭，无暴发性肝损伤。
Br Med J (Clin Res Ed). 1982 Feb 13;284(6314):505-6. doi: 10.1136/bmj.284.6314.505-d.
4
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.对乙酰氨基酚引起的急性肾衰竭，无暴发性肝损伤。
Br Med J (Clin Res Ed). 1982 Jan 2;284(6308):21-2. doi: 10.1136/bmj.284.6308.21.
5
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.对乙酰氨基酚引起的急性肾衰竭，无暴发性肝损伤。
Br Med J (Clin Res Ed). 1982 Feb 6;284(6313):421-2. doi: 10.1136/bmj.284.6313.421-d.
6
Digoxin-like immunoreactive substances in severe acute liver disease due to viral hepatitis and paracetamol overdose.
Hepatology. 1988 Jan-Feb;8(1):93-7. doi: 10.1002/hep.1840080119.
7
[Acute kidney failure caused by paracetamol poisoning].[对乙酰氨基酚中毒所致急性肾衰竭]
Nefrologia. 2001;21(6):592-5.
8
9
Paracetamol (acetaminophen) poisoning resulting in acute renal failure without hepatic coma.对乙酰氨基酚中毒导致急性肾衰竭，无肝昏迷。
Nephron. 1988;50(1):55-6. doi: 10.1159/000185117.
10
Classification, etiology, and considerations of outcome in acute liver failure.急性肝衰竭的分类、病因及预后考量
Semin Liver Dis. 1996 Nov;16(4):343-8. doi: 10.1055/s-2007-1007247.
引用本文的文献
1
Hypophosphatemia in acute liver failure of a broad range of etiologies is associated with phosphaturia without kidney damage or phosphatonin elevation.各种病因引起的急性肝衰竭患者常发生低磷血症，其发生机制为无肾脏损伤和甲状旁腺素升高的磷尿。
Transl Res. 2021 Dec;238:1-11. doi: 10.1016/j.trsl.2021.07.003. Epub 2021 Jul 21.
2
Effect of Ketorolac on the Prevention of Postoperative Catheter-Related Bladder Discomfort in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy: A Randomized, Double-Blinded, Placebo-Controlled Study.酮咯酸对机器人辅助腹腔镜根治性前列腺切除术患者术后导尿管相关膀胱不适的预防作用：一项随机、双盲、安慰剂对照研究。
J Clin Med. 2019 May 29;8(6):759. doi: 10.3390/jcm8060759.
3
Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms.对乙酰氨基酚的肝外毒性：证据的批判性评估及提出的机制
J Clin Transl Res. 2017 Nov 18;3(3):297-310. doi: 10.18053/jctres.03.201703.005. eCollection 2018 Jan 15.
4
Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting List.美国肝移植等待名单上急性肝衰竭患者肾功能不全的患病率、严重程度及影响
Dig Dis Sci. 2016 Jan;61(1):309-16. doi: 10.1007/s10620-015-3870-y. Epub 2015 Sep 19.
5
Acute kidney injury following acute liver failure: potential role of systemic cadmium mobilization?急性肝衰竭后急性肾损伤：全身性镉动员的潜在作用？
Intensive Care Med. 2012 Mar;38(3):467-73. doi: 10.1007/s00134-011-2449-0. Epub 2012 Jan 12.
6
Paracetamol: new vistas of an old drug.对乙酰氨基酚：一种老药的新前景。
CNS Drug Rev. 2006 Fall-Winter;12(3-4):250-75. doi: 10.1111/j.1527-3458.2006.00250.x.
7
Investigation of the renal injury caused by liver ischemia-reperfusion in rats.大鼠肝脏缺血再灌注所致肾损伤的研究
Arch Toxicol. 1993;67(7):502-9. doi: 10.1007/BF01969922.
8
Progress in the management of fulminant hepatic failure.暴发性肝衰竭的治疗进展
Intensive Care Med. 1981 Apr;7(3):101-3. doi: 10.1007/BF01738610.
9
The metabolism and toxicity of paracetamol in Sprague-Dawley and Wistar rats.对乙酰氨基酚在斯普拉格-道利大鼠和Wistar大鼠体内的代谢与毒性
Eur J Drug Metab Pharmacokinet. 1982;7(3):203-22. doi: 10.1007/BF03189567.
10
Analgesic nephropathy: a reassessment of the role of phenacetin and other analgesics.镇痛剂肾病：对非那西丁及其他镇痛剂作用的重新评估
Drugs. 1982 Jan-Feb;23(1-2):75-149. doi: 10.2165/00003495-198223010-00004.
本文引用的文献
1
EFFECTS OF ENDOTOXIN ON RENAL FUNCTION AND HEMODYNAMICS.内毒素对肾功能和血流动力学的影响。
Am J Physiol. 1963 Aug;205:293-7. doi: 10.1152/ajplegacy.1963.205.2.293.
2
On the absorption of bacterial endotoxin from the gastro-intestinal tract of the normal and shocked animal.关于正常动物和休克动物胃肠道对细菌内毒素的吸收
J Exp Med. 1960 Nov 1;112(5):783-92. doi: 10.1084/jem.112.5.783.
3
Paracetamol and the kidney.对乙酰氨基酚与肾脏
Br Med J. 1967 Jun 3;2(5552):615-6. doi: 10.1136/bmj.2.5552.615.
4
Acute liver necrosis following overdose of paracetamol.对乙酰氨基酚过量导致的急性肝坏死。
Br Med J. 1966 Aug 27;2(5512):497-9. doi: 10.1136/bmj.2.5512.497.
5
Paracetamol and renal damage.对乙酰氨基酚与肾损伤。
Br Med J. 1971 Apr 10;2(5753):87-9. doi: 10.1136/bmj.2.5753.87.
6
Comparative nephrotoxicity of aspirin and phenacetin derivatives.
Br Med J. 1971 Nov 27;4(5786):518-21. doi: 10.1136/bmj.4.5786.518.
7
General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat.非那西丁、对乙酰氨基酚及某些抗有丝分裂剂对大鼠的全身毒性和肾毒性
Arch Toxikol. 1972;28(4):225-69. doi: 10.1007/BF00330059.
8
A technique for quantitative measurement of endotoxin in human plasma.一种定量测量人血浆中内毒素的技术。
Proc Soc Exp Biol Med. 1971 May;137(1):334-40. doi: 10.3181/00379727-137-35572.
9
Frequency and type of renal and electrolyte disorders in fulminant hepatic failure.暴发性肝衰竭中肾脏和电解质紊乱的频率及类型
Br Med J. 1974 Feb 2;1(5900):186-9. doi: 10.1136/bmj.1.5900.186.
10
Nonspecificity of the limulus amebocyte lysate test: positive reactions with polynucleotides and proteins.鲎试剂检测的非特异性：与多核苷酸和蛋白质的阳性反应。
J Infect Dis. 1973 Sep;128(3):349-52. doi: 10.1093/infdis/128.3.349.
Zotero 插件