Wilkinson S P, Moodie H, Arroyo V A, Williams R
J Clin Pathol. 1977 Feb;30(2):141-3. doi: 10.1136/jcp.30.2.141.
In an analysis of 160 patients with fulminant hepatic failure, the frequency of renal failure in the patiens who had taken an overdose of paracetamol was not significantly higher than in those with hepatic failure due to other causes. The same was found in another group of patients with less severe hepatic damage. In both the latter group and the patients with fulminant hepatic failure, the development of renal failure was closely related to the occurrence of endotoxaemia as detected by the Limulus lysate assay. These findings do not support the concept that an overdose of paracetamol has a specific nephrotoxic effect.
在一项对160例暴发性肝衰竭患者的分析中，服用过量扑热息痛的患者肾衰竭发生率并不显著高于因其他原因导致肝衰竭的患者。在另一组肝损伤较轻的患者中也发现了同样的情况。在后一组患者和暴发性肝衰竭患者中，肾衰竭的发生与鲎试剂检测所发现的内毒素血症的发生密切相关。这些发现并不支持过量服用扑热息痛具有特定肾毒性作用这一观点。
