转化生长因子-β1存在于阿尔茨海默病和唐氏综合征病变的斑块中。

Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies.

作者信息

van der Wal E A, Gómez-Pinilla F, Cotman C W

机构信息

Department of Psychobiology, University of California, Irvine 92717-4550.

出版信息

Neuroreport. 1993 Jan;4(1):69-72. doi: 10.1097/00001756-199301000-00018.

DOI:10.1097/00001756-199301000-00018

PMID:8453039

Abstract

Transforming growth factor-beta (TGF-beta) is a major modulator of the extracellular matrix and cell growth, and shows affinity for and interaction with several substances present in plaques in Alzheimer's disease (AD). In order to examine a possible role of TGF-beta in plaque biogenesis, we studied its distribution in the limbic system of AD and Down's syndrome (DS) brains. Select plaques displayed TGF-beta 1 immunoreactivity in AD and DS. TGF-beta 1 plaques were mainly located in the molecular layer of the dentate gyrus in AD, while in DS TGF-beta 1 plaques were preferentially located in the entorhinal cortex. In AD, TGF-beta 1 immunoreactivity was also shown in neurofibrillary tangles. The presence of TGF-beta 1 in plaques suggests that TGF-beta 1 may play a role in the cascade of events leading to plaque formation.

摘要

转化生长因子-β（TGF-β）是细胞外基质和细胞生长的主要调节因子，并且对阿尔茨海默病（AD）斑块中存在的几种物质具有亲和力并与其相互作用。为了研究TGF-β在斑块生物发生中的可能作用，我们研究了其在AD和唐氏综合征（DS）大脑边缘系统中的分布。在AD和DS中，部分斑块显示出TGF-β1免疫反应性。AD中TGF-β1斑块主要位于齿状回分子层，而DS中TGF-β1斑块优先位于内嗅皮质。在AD中，神经原纤维缠结中也显示出TGF-β1免疫反应性。斑块中TGF-β1的存在表明TGF-β1可能在导致斑块形成的一系列事件中发挥作用。