Ohlin A, Lerner U H
Department of Orthopaedics, Malmö General Hospital (Lund University), Sweden.
Bone Miner. 1993 Jan;20(1):67-78. doi: 10.1016/s0169-6009(08)80038-4.
Using bone organ culture techniques, we studied the production of bone-resorption stimulating factors by the different tissues surrounding loosened total hip arthroplasties. Revision arthroplasties were performed in 13 patients. Various periprosthetic tissues were obtained from these patients. Culture media conditioned by the newly formed capsules contained higher bone-resorption activity when compared to the resorptive activity found in media conditioned by bone-cement membranes. Addition of indomethacin or structurally unrelated non-steroidal anti-inflammatory drugs, or corticosteroids, to bone-cement membrane cultures altered the process of bone resorption in the vicinity of cemented joint implants suggesting that both prostaglandin and other mediators may be involved in the mechanism by which bone-resorbing osteoclasts are stimulated. Our observations indicate that, in the sequence of events that leads to loosening of implants, mediators released from the joint capsules may be more important than those produced by the bone-cement membranes.
利用骨器官培养技术，我们研究了全髋关节置换术松动周围不同组织产生骨吸收刺激因子的情况。对13例患者进行了翻修关节成形术。从这些患者身上获取了各种假体周围组织。与骨水泥膜条件培养基中的吸收活性相比，新形成的囊膜条件培养基具有更高的骨吸收活性。向骨水泥膜培养物中添加吲哚美辛或结构不相关的非甾体抗炎药或皮质类固醇，改变了骨水泥固定关节植入物附近的骨吸收过程，这表明前列腺素和其他介质可能参与了刺激破骨细胞进行骨吸收的机制。我们的观察结果表明，在导致植入物松动的一系列事件中，从关节囊释放的介质可能比骨水泥膜产生的介质更重要。
