Appel A M, Sowder W G, Siverhus S W, Hopson C N, Herman J H
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio.
Br J Rheumatol. 1990 Feb;29(1):32-6. doi: 10.1093/rheumatology/29.1.32.
A pseudomembranous structure invariably develops at the cement-bone interface of implanted prostheses in association with aseptic loosening. The tissue has histological characteristics of a foreign body reaction presumably initiated by repetitive microtrauma-associated release of methacrylate cement and polyethylene wear debris. Explant cultures of pseudomembrane and synovial tissue derived from osteoarthritic patients undergoing revision for cemented hip implant failure have been shown to produce interleukin-1, tumour necrosis factor and prostaglandin E2, recognized mediators of bone resorption. Further, the conditioned media obtained from pseudomembrane cultures could directly effect bone resorption by inducing 45Ca release from prelabelled limb bone rudiments. Results implicate the prosthesis-associated pseudomembrane in the pathogenesis of the bone resorptive process responsible for prosthesis failure.
在与无菌性松动相关的植入假体的骨水泥 - 骨界面处，总会形成假膜结构。该组织具有异物反应的组织学特征，推测是由甲基丙烯酸酯骨水泥和聚乙烯磨损颗粒反复微创伤相关释放引发的。来自接受骨水泥型髋关节置换失败翻修术的骨关节炎患者的假膜和滑膜组织的外植体培养物已被证明可产生白细胞介素 -1、肿瘤坏死因子和前列腺素E2，这些都是公认的骨吸收介质。此外，从假膜培养物中获得的条件培养基可通过诱导预标记的肢体骨雏形释放45Ca直接影响骨吸收。结果表明，假体相关假膜参与了导致假体失败的骨吸收过程的发病机制。
