Elkeles A
J Am Geriatr Soc. 1977 Apr;25(4):179-85. doi: 10.1111/j.1532-5415.1977.tb00289.x.
The paradoxic biologic behavior of tissue calcium metabolism is emphasized. Although calcium salts are essential for the development of bones, they also contribute to aging of the large human arteries. The heavy elements providing alpha-ray activity tend to be metabolized like calcium. The concept of an osteoporosis-atherosclerosis relationship led to a series of investigations in which ash content and alpha-ray activity were examined in abdominal aortas, coronary arteries, pulmonary arteries and, for comparison, in bones and ventral costal cartilages. Both ash content and alpha-ray activity rise with age in the aorta and in the coronary arteries, but there is no such increase in the pulmonary arteries. A statistically significant correlation between ash content and alpha-ray activity has been found only in aortas and coronary arteries. This correlation is even closer in the coronary arteries of subjects who die of coronary artery disease and in the aortas of the elderly. Wet tissue alpha-ray activity in an aorta with severe atherosclerosis may be 220 times higher than in an aorta without significant atherosclerosis. Alpha-activity in bones and in ventral costal cartilages tends to decline in advancing years, though in the cartilages the calcium deposits increase with age. Our studies reveal a close relationship between atherogenesis and the unique metabolic behavior of alpha-ray radiation in the large human arteries.
强调了组织钙代谢的反常生物学行为。虽然钙盐对骨骼发育至关重要，但它们也会促使人类大动脉老化。具有α射线活性的重元素往往像钙一样进行代谢。骨质疏松症与动脉粥样硬化关系的概念引发了一系列研究，其中对腹主动脉、冠状动脉、肺动脉进行了灰分含量和α射线活性检测，并与骨骼和肋软骨进行对比。主动脉和冠状动脉的灰分含量及α射线活性均随年龄增长而升高，但肺动脉中则无此增长。仅在主动脉和冠状动脉中发现灰分含量与α射线活性之间存在统计学显著相关性。在死于冠状动脉疾病者的冠状动脉以及老年人的主动脉中，这种相关性更为紧密。严重动脉粥样硬化的主动脉中湿组织α射线活性可能比无明显动脉粥样硬化的主动脉高220倍。随着年龄增长，骨骼和肋软骨中的α活性趋于下降，不过在肋软骨中钙沉积会随年龄增加。我们的研究揭示了动脉粥样硬化形成与人类大动脉中α射线辐射独特代谢行为之间的密切关系。
