Salinsky M C, Burchiel K J
Department of Neurology, Oregon Health Sciences University, Portland 97201.
Epilepsia. 1993 Mar-Apr;34(2):299-304. doi: 10.1111/j.1528-1157.1993.tb02415.x.
Vagus nerve stimulation (VNS) has been shown to have an anticonvulsant effect in several animal models, and clinical trials in patients were recently started. Experimental data have suggested that VNS may act by modulating EEG rhythmic activity. We studied the acute effects of VNS on EEG background rhythms in patients undergoing treatment for poorly controlled partial seizures. Six patients had recordings of satisfactory quality for quantitative EEG analysis. A significant effect of VNS on EEG total power, median frequency, or power in any of the conventional frequency bands, could not be demonstrated. Intraindividual analysis did not show a significant effect of VNS on total power for any patient, including those with apparent clinical response. We conclude that VNS at the parameters in current clinical use does not alter awake EEG background rhythms. The mechanism mediating acute antiepileptic effect remains unknown.
迷走神经刺激（VNS）已在多种动物模型中显示出抗惊厥作用，近期已开始针对患者的临床试验。实验数据表明，VNS可能通过调节脑电图节律活动发挥作用。我们研究了VNS对部分性癫痫控制不佳正在接受治疗的患者脑电图背景节律的急性影响。6例患者的记录质量足以进行定量脑电图分析。未证实VNS对脑电图总功率、中位频率或任何传统频段的功率有显著影响。个体内分析未显示VNS对任何患者的总功率有显著影响，包括那些有明显临床反应的患者。我们得出结论，当前临床使用参数下的VNS不会改变清醒状态下的脑电图背景节律。介导急性抗癫痫作用的机制仍不清楚。
