Gray D S, Sharma R C, Chin H P, Jiao Q, Kramsch D M
Department of Family Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Exp Mol Pathol. 1993 Feb;58(1):53-60. doi: 10.1006/exmp.1993.1005.
Considerable variability exists among individuals in the response of plasma cholesterol to changes in dietary fat and cholesterol, and obesity is one variable reported to affect this response. This study was performed to determine the relationship between body fat and changes in plasma cholesterol in cynomolgus monkeys fed a high-fat cholesterol-containing diet for 12 months. The animals gained significant body weight (body mass index increased from 30.5 +/- 0.5 to 35.7 +/- 2.8 kg/m2) and skinfold parameters of body fat increased as well. Total cholesterol increased from 109 +/- 4 to 390 +/- 25 mg/dl (P < 0.001), and there were also significant increases in LDL- and HDL-cholesterol and triglyceride. While there was very little relationship between body fat and plasma lipids before the diet, after 12 months, there were significant negative correlations between total and LDL-cholesterol and anthropometric measures of body fat (r ranged from -0.37 to -0.55, P < 0.01). The correlations were not affected when the effects of baseline body mass index and serum cholesterol and total food intake were controlled by partial correlation analysis. In this sample of animals, the acquisition of greater body fat appeared to protect against rises in cholesterol in response to consumption of a high-fat cholesterol-containing diet.
个体之间血浆胆固醇对饮食中脂肪和胆固醇变化的反应存在很大差异，肥胖是据报道会影响这种反应的一个变量。本研究旨在确定食蟹猴在喂食含高脂肪胆固醇饮食12个月后，体脂与血浆胆固醇变化之间的关系。动物体重显著增加（体重指数从30.5±0.5增加到35.7±2.8kg/m²），体脂的皮褶参数也增加。总胆固醇从109±4增加到390±25mg/dl（P<0.001），低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯也显著增加。在饮食前，体脂与血脂之间几乎没有关系，但12个月后，总胆固醇和低密度脂蛋白胆固醇与体脂的人体测量指标之间存在显著负相关（r范围为-0.37至-0.55，P<0.01）。通过偏相关分析控制基线体重指数、血清胆固醇和总食物摄入量的影响后，相关性不受影响。在这个动物样本中，获得更多体脂似乎可以防止因食用含高脂肪胆固醇饮食而导致的胆固醇升高。
