Quesniaux V F, Mayer P, Liehl E, Turner K, Goldman S J, Fagg B
Preclinical Research, Sandoz Pharma Ltd., Basel, Switzerland.
Int Rev Exp Pathol. 1993;34 Pt A:205-14.
The novel stromal cell factor, IL-11, has been reported to have diverse effects on the lymphopoietic and myeloid/erythroid cells in vitro. These include expansion of T cell-dependent Ig-secreting B cells, proliferation and differentiation of megakaryocytic progenitors and of a variety of myeloid and erythroid precursor cells, and multiplication of pluripotential hematopoietic progenitors. In addition, IL-11 inhibits adipogenesis in vitro. In vivo administration of IL-11 elevated the number of circulating neutrophils and platelets and increased the number of megakaryocytes in the spleens of normal mice.
据报道，新型基质细胞因子白细胞介素-11（IL-11）在体外对淋巴细胞生成及髓系/红系细胞具有多种作用。这些作用包括依赖T细胞的分泌免疫球蛋白的B细胞的扩增、巨核细胞祖细胞以及多种髓系和红系前体细胞的增殖与分化，还有多能造血祖细胞的增殖。此外，IL-11在体外可抑制脂肪生成。在正常小鼠体内给予IL-11可提高循环中性粒细胞和血小板的数量，并增加脾脏中巨核细胞的数量。
