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Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor.

作者信息

Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I

机构信息

Department of Developmental Biology, Amgen Inc., Amgen Center, Thousand Oaks, California 91320.

出版信息

Mol Cell Biol. 1994 Feb;14(2):1431-7. doi: 10.1128/mcb.14.2.1431-1437.1994.

DOI:10.1128/mcb.14.2.1431-1437.1994
PMID:8289818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC358498/
Abstract

A novel gene coding for the pre-B-cell colony-enhancing factor (PBEF) has been isolated from a human peripheral blood lymphocyte cDNA library. The expression of this gene is induced by pokeweed mitogen and superinduced by cycloheximide. It is also induced in the T-lymphoblastoid cell line HUT 78 after phorbol ester (phorbol myristate acetate) treatment. The predominant mRNA for PBEF is approximately 2.4 kb long and codes for a 52-kDa secreted protein. The 3' untranslated region of the mRNA has multiple TATT motifs, usually found in cytokine and oncogene messages. The PBEF gene is mainly transcribed in human bone marrow, liver tissue, and muscle. We have expressed PBEF in COS 7 and PA317 cells and have tested the biological activities of the conditioned medium as well as the antibody-purified protein in different in vitro assays. PBEF itself had no activity but synergized the pre-B-cell colony formation activity of stem cell factor and interleukin 7. In the presence of PBEF, the number of pre-B-cell colonies was increased by at least 70% above the amount stimulated by stem cell factor plus interleukin 7. No effect of PBEF was found with cells of myeloid or erythroid lineages. These data define PBEF as a novel cytokine which acts on early B-lineage precursor cells.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ca/358498/9d392df9b17e/molcellb00002-0577-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ca/358498/c7788075f236/molcellb00002-0576-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ca/358498/c781da427e55/molcellb00002-0576-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ca/358498/bb34b0478345/molcellb00002-0577-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ca/358498/9d392df9b17e/molcellb00002-0577-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ca/358498/c7788075f236/molcellb00002-0576-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ca/358498/c781da427e55/molcellb00002-0576-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ca/358498/bb34b0478345/molcellb00002-0577-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ca/358498/9d392df9b17e/molcellb00002-0577-b.jpg

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Recombinant CD40 ligand stimulation of murine B cell growth and differentiation: cooperative effects of cytokines.重组CD40配体对小鼠B细胞生长和分化的刺激作用:细胞因子的协同效应
内脂素对猪着床期前垂体细胞转录组图谱的影响。
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