Shortland P, Woolf C J
Department of Anatomy and Developmental Biology, University College London, England.
J Comp Neurol. 1993 Mar 22;329(4):491-511. doi: 10.1002/cne.903290406.
The central arborizations in the dorsal horn of the spinal cord of 23 rapidly adapting (RA) A-beta primary afferent neurons innervating different regions of the glabrous skin of the hindpaw were studied by the intra-axonal injection of horseradish peroxidase in adult rats. A total of 284 arbors of the complex, simple, and blind-ending variety were recovered. The arbors of RA afferents innervating the toes, paw pads, and non-pad hindpaw differed from each other in branch pattern and dimensions. The simple and complex arbors, which are both bouton-containing, were distributed mainly in laminae III-V, although some complex arbors projected dorsally into lamina IIi. The hindpaw glabrous skin afferent terminals were located in the lumbar enlargement from caudal L3 to rostral L6. A crude somatotopic organization was observed such that toes 1-5 were represented successively in more caudal positions from mid-L4 to caudal L5. The paw pads were organized in a rostrocaudal sequence moving from the paw pads proximal to toe 1 across the foot to the paw pads proximal to toe 5, from caudal L3 to mid-L5. Non-pad hindpaw afferents were located in caudal L5. Overlap between toe, paw pad and non-pad afferent central fields was present, however, and the central terminals of afferents with non-adjacent peripheral receptive fields were shown to occupy the same region of the dorsal horn.
在成年大鼠中，通过向轴突内注射辣根过氧化物酶，研究了23个支配后足无毛皮肤不同区域的快速适应性（RA）A-β初级传入神经元在脊髓背角的中央分支。共回收了284个复杂、简单和盲端型分支。支配脚趾、爪垫和非爪垫后足的RA传入神经分支在分支模式和尺寸上彼此不同。含有终扣的简单和复杂分支主要分布在III - V层，尽管一些复杂分支背侧投射到IIi层。后足无毛皮肤传入神经末梢位于从L3尾段到L6头段的腰膨大处。观察到一种粗略的躯体定位组织，使得1 - 5趾在从L4中部到L5尾段的更尾侧位置依次代表。爪垫以从靠近趾1的爪垫向足的近端穿过足部到靠近趾5的爪垫的头尾顺序排列，从L3尾段到L5中部。非爪垫后足传入神经位于L5尾段。然而，趾、爪垫和非爪垫传入神经中枢野之间存在重叠，并且具有不相邻外周感受野的传入神经的中枢终末被证明占据背角的同一区域。
