Ohman J L, Sparrow D, MacDonald M R
New England Medical Center, Tufts University, School of Medicine, Boston, MA 02111.
J Allergy Clin Immunol. 1993 Mar;91(3):752-7. doi: 10.1016/0091-6749(93)90195-l.
Thirty-nine male subjects, with new-onset wheezing, were selected from participants in the Department of Veterans Affairs Normative Aging Study and compared with 74 age-matched controls. Wheezing was defined by responses to a standardized and regularly administered questionnaire. The subjects with wheezing had a reduced FEV1 compared with controls (p = 0.005), but most had values above 80% predicted. Current smoking was more common in subjects with wheezing (36.8% vs 8.11% in controls, p < 0.001). The mean age of both subjects and controls was 64 years.
Allergen-specific IgE antibodies were measured, starting with sera at the time of the most recent questionnaire, and on the average 3.1, 7.6, and 12.3 years before that, with use of stored serum samples.
Total IgE did not differ significantly between the groups. IgE binding to dust mite antigen was detected in 13% to 15% of the subjects with wheezing compared with fewer than 7% of the controls over four time intervals (p = 0.014). IgE binding to cat and ragweed antigens did not differ significantly between groups. If current nonsmokers were analyzed separately, IgE binding to cat allergen was also slightly greater in subjects with wheezing compared with controls (p = 0.054). Sequential analysis of IgE antibody levels to mite antigen, over time, indicated that IgE antibody antedated the onset of wheezing.
New-onset wheezing in an older adult male population is significantly associated with allergic sensitization to dust mite. There was a borderline association with sensitization to cat in noncurrent smokers only. This supports the hypothesis that a subgroup may have allergic triggers to their symptoms.
从退伍军人事务部规范性衰老研究的参与者中选取了39名新发喘息的男性受试者，并与74名年龄匹配的对照者进行比较。喘息通过对标准化且定期发放的问卷的回答来定义。与对照组相比，喘息受试者的第一秒用力呼气容积（FEV1）降低（p = 0.005），但大多数人的数值高于预测值的80%。当前吸烟者在喘息受试者中更为常见（36.8% 对比对照组的8.11%，p < 0.001）。受试者和对照者的平均年龄均为64岁。
从最近一次问卷调查时的血清开始，使用储存的血清样本，平均在那之前3.1年、7.6年和12.3年测量过敏原特异性IgE抗体。
两组之间总IgE无显著差异。在四个时间间隔内，13%至15%的喘息受试者检测到IgE与尘螨抗原结合，而对照组中这一比例不到7%（p = 0.014）。两组之间IgE与猫和豚草抗原的结合无显著差异。如果单独分析当前不吸烟者，喘息受试者中IgE与猫过敏原的结合也略高于对照组（p = 0.054）。随着时间的推移，对尘螨抗原的IgE抗体水平进行序贯分析表明，IgE抗体早于喘息发作。
老年男性人群中的新发喘息与对尘螨的过敏致敏显著相关。仅在当前不吸烟者中与对猫的致敏存在临界关联。这支持了一个亚组的症状可能有过敏触发因素的假设。
