Yu Meng-Kung, Lin Ching-Yuang, Chen Woan-Ling, Chen Ching-Tung
Department of Pediatrics, Changhua Christian Hospital, Changhua, Taiwan.
J Microbiol Immunol Infect. 2008 Feb;41(1):68-73.
In a previous study, we found that wheezing children in rural central Taiwan had a significantly lower average sensitization rate to Dermatophagoides pteronyssinus (Der p) than those in Taipei city. We propose that Blomia tropicalis (Blo t) might be the major mite allergen in rural central Taiwan.
Using the preserved sera from our previous study, we retrospectively measured specific immunoglobulin E (IgE) antibody to Blo t and analyzed the correlation between Blo t and Der p in wheezing children in rural central Taiwan. A total of 2206 children with physician-diagnosed asthma and wheezing were enrolled and categorized among five age groups. The sensitization rate and level of specific IgE antibody to Blo t were analyzed.
The age-specific sensitization rates and the level of specific IgE antibody to either Blo t or Der p increased progressively with increasing age, being greatest in the age group 8 to 12 years. A significant positive correlation existed between sensitization rate and age for both Blo t and Der p (p=0.001). Specific IgE antibody to Blo t was undetectable in patients younger than 1.5 years. A significant positive correlation also existed between age and anti-Blo t IgE antibody level (p<0.003). However, the allergen-specific IgE level was lower for Blo t than Der p (p<0.005) in all age groups.
Blo t might be the major mite allergen to associated with early wheeze and atopic asthma in rural central Taiwan.
在之前的一项研究中，我们发现台湾中部农村地区的喘息儿童对屋尘螨（Der p）的平均致敏率显著低于台北市的儿童。我们提出热带无爪螨（Blo t）可能是台湾中部农村地区主要的螨过敏原。
利用我们之前研究中保存的血清，我们回顾性地检测了台湾中部农村地区喘息儿童针对Blo t的特异性免疫球蛋白E（IgE）抗体，并分析了Blo t与Der p之间的相关性。共有2206名经医生诊断为哮喘和喘息的儿童入组，并分为五个年龄组。分析了针对Blo t的致敏率和特异性IgE抗体水平。
针对Blo t或Der p的年龄特异性致敏率和特异性IgE抗体水平随年龄增长而逐渐升高，在8至12岁年龄组中最高。Blo t和Der p的致敏率与年龄之间均存在显著正相关（p = 0.001）。1.5岁以下患者中未检测到针对Blo t的特异性IgE抗体。年龄与抗Blo t IgE抗体水平之间也存在显著正相关（p < 0.003）。然而，在所有年龄组中，Blo t的过敏原特异性IgE水平均低于Der p（p < 0.005）。
Blo t可能是与台湾中部农村地区早期喘息和特应性哮喘相关的主要螨过敏原。
