有证据表明，在腔静脉急性缩窄期间，心输出量降低并非钠潴留的刺激因素。

Evidence that decreased cardiac output is not the stimulus to sodium retention during acute constriction of the vena cava.

作者信息

Migdal S, Alexander E A, Levinsky N G

出版信息

J Lab Clin Med. 1977 Apr;89(4):809-16.

Abstract

It has been proposed that the antinatriuresis during constriction of the TVC is due to a decrease in CO. We have compared the effect on sodium excretion of comparable reductions in CO by three separate methods: TVC constriction, PA occlusion, and LV infarction. Dogs were studied during 10% of body weight saline loading and again after TVC constriction, PA occlusion, or LV infarction. CO fell 26 to 31% in all groups; sodium excretion was not significantly altered after PA occlusion (474 to 533 micronEq/min.) or LV infarction (587 to 609 micronEq/min.) but fell significantly after TVC constriction (504 to 271 micronEq/min.). Renal and systemic hemodynamoderate reduction of CO per se does not cause sodium retention. PA and TVC dogs had comparable increments in vena caval pressure but opposite changes in RVEDP; 4 to 0.9 mm. Hg (TVC) and 0.5 to 9.1 mm. Hg (PA).

摘要

有人提出，下腔静脉（TVC）缩窄时的钠潴留是由于心输出量（CO）降低所致。我们通过三种不同方法比较了同等程度降低CO对钠排泄的影响：TVC缩窄、肺动脉（PA）阻塞和左心室梗死。在给予体重10%的生理盐水负荷期间以及TVC缩窄、PA阻塞或左心室梗死后，对犬进行了研究。所有组的CO均下降了26%至31%；PA阻塞（474至533微当量/分钟）或左心室梗死后（587至609微当量/分钟）钠排泄无显著变化，但TVC缩窄后（504至271微当量/分钟）钠排泄显著下降。肾脏和全身血流动力学表明，CO本身的适度降低不会导致钠潴留。PA组和TVC组犬的腔静脉压力有相当程度的升高，但右心室舒张末期压力（RVEDP）变化相反；分别为4至0.9毫米汞柱（TVC组）和0.5至9.1毫米汞柱（PA组）。