Foley N M, Miller R F
University College and Middlesex School of Medicine, Department of Medicine, Middlesex Hospital, London, U.K.
J Infect. 1993 Jan;26(1):39-43. doi: 10.1016/0163-4453(93)96776-m.
We have studied the effect of the HIV epidemic on the incidence of tuberculosis in an inner city area of London which has a high incidence of acquired immunodeficiency syndrome (AIDS). During the period 1985-1991, there was a steady increase in the number of new AIDS cases, whilst the numbers of notifications and laboratory isolates of Mycobacterium tuberculosis remained largely unchanged. Before 1990 there were few cases of tuberculosis in HIV-infected individuals but in the past 2 years there has been a marked increase. In 44% of patients, the site of infection was pulmonary, in 39% extrapulmonary and in 17% pulmonary and extrapulmonary. There were no previous manifestations of immunodeficiency in 58% of patients. This is the first study to show an association between tuberculosis and HIV in the U.K. and supports the suggestion that there is an increased incidence of tuberculosis in patients with HIV infection who are not intravenous drug users.
我们研究了艾滋病流行对伦敦一个市中心城区结核病发病率的影响，该城区获得性免疫缺陷综合征（艾滋病）发病率很高。在1985年至1991年期间，新艾滋病病例数量稳步上升，而结核分枝杆菌的通报病例数和实验室分离株数量基本保持不变。1990年以前，HIV感染个体中的结核病病例很少，但在过去两年中显著增加。44%的患者感染部位为肺部，39%为肺外，17%为肺内和肺外。58%的患者既往无免疫缺陷表现。这是英国第一项显示结核病与HIV之间存在关联的研究，并支持了非静脉吸毒的HIV感染患者结核病发病率增加这一观点。
