Satomura Y, Sawabu N, Ohta H, Watanabe H, Yamakawa O, Motoo Y, Okai T, Toya D, Makino H, Okamoto H
Department of Internal Medicine, Kanazawa University, Japan.
Int J Pancreatol. 1993 Feb;13(1):59-67. doi: 10.1007/BF02795200.
In order to elucidate the characteristics of reg-protein, which is identical to pancreatic stone protein (PSP/reg-protein), and the relationship between the generation and evolution of chronic pancreatitis and the expression of PSP/reg-protein in the pancreas, we investigated the expression of PSP/reg-protein in normal and diseased human pancreatic tissues by immunohistochemistry. The PSP/reg-protein was expressed in all cases with normal pancreas or chronic pancreatitis, and in 70.6% of cases with pancreatic cancer. This protein was present in the cytoplasm of acinar cells and, in some cases, in the intraluminal contents of ductules in nonmalignant tissues. From the view of distribution and cellular localization, PSP/reg-protein was expressed more broadly and densely in chronic pancreatitis with mild to moderate injury than in the normal pancreas. However, the protein was less expressed in severely damaged chronic pancreatitis tissue, such as calcifying pancreatitis, than in the normal pancreas. These findings suggest that mild to moderate injury to pancreatic tissue may stimulate the synthesis of PSP/reg-protein, whereas more severe injury tends to depress it.
为了阐明与胰石蛋白（PSP/reg蛋白）相同的reg蛋白的特性，以及慢性胰腺炎的发生发展与胰腺中PSP/reg蛋白表达之间的关系，我们采用免疫组织化学方法研究了PSP/reg蛋白在正常和病变人胰腺组织中的表达情况。PSP/reg蛋白在所有正常胰腺或慢性胰腺炎病例中均有表达，在70.6%的胰腺癌病例中也有表达。该蛋白存在于腺泡细胞的细胞质中，在某些情况下，也存在于非恶性组织中小导管的管腔内物质中。从分布和细胞定位来看，与正常胰腺相比，PSP/reg蛋白在轻度至中度损伤的慢性胰腺炎中表达更广泛、更密集。然而，与正常胰腺相比，在严重受损的慢性胰腺炎组织（如钙化性胰腺炎）中该蛋白表达较少。这些发现表明，胰腺组织的轻度至中度损伤可能刺激PSP/reg蛋白的合成，而更严重的损伤则倾向于抑制其合成。
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