Multigner L, Sarles H, Lombardo D, De Caro A
Gastroenterology. 1985 Aug;89(2):387-91. doi: 10.1016/0016-5085(85)90341-5.
Pancreatic stone protein, a novel protein isolated from pancreatic stones of patients suffering from chronic calcifying pancreatitis and secreted in normal human pancreatic juice, was measured by radial immunodiffusion in pure pancreatic juice. Patients with chronic calcifying pancreatitis of different etiologies had significantly lower levels of pancreatic stone protein when compared with other pancreatic diseases and controls. Pancreatic stone protein suppresses in vitro calcium carbonate precipitation and therefore stabilizes normally supersaturated pancreatic juice. The decreased pancreatic stone protein levels observed could be a key factor in the growth of calcium carbonate crystals and stone development during the course of chronic calcifying pancreatitis.
胰石蛋白是一种从慢性钙化性胰腺炎患者的胰石中分离出的新型蛋白质，正常情况下在人胰液中分泌，采用放射免疫扩散法在纯胰液中对其进行测定。与其他胰腺疾病及对照组相比，不同病因的慢性钙化性胰腺炎患者的胰石蛋白水平显著降低。胰石蛋白可抑制体外碳酸钙沉淀，因此可使正常时处于过饱和状态的胰液保持稳定。所观察到的胰石蛋白水平降低可能是慢性钙化性胰腺炎病程中碳酸钙晶体生长及结石形成的关键因素。
