Freedman David S, Katzmarzyk Peter T, Dietz William H, Srinivasan Sathanur R, Berenson Gerald S
Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta GA 30341-3724, USA.
Ann Hum Biol. 2010 Nov;37(6):726-37. doi: 10.3109/03014461003641849. Epub 2010 May 7.
Although adverse levels of cardiovascular disease risk factors are related to skinfold thicknesses and BMI among adults, the relative strengths of these associations are unknown. We examine whether the triceps and subscapular skinfold thicknesses are more strongly related to adult levels of lipids, fasting insulin and blood pressure than BMI.
Cross-sectional (n =3318) and longitudinal (n =1593) analyses of 18- to 44-year-olds examined in the Bogalusa Heart Study from 1983 to 2002. Principal components analysis was used to derive a summary index of the six examined risk factors (triglycerides, low- and high-density lipoprotein cholesterol, insulin, and systolic and diastolic blood pressures).
The magnitudes of the differences were generally small, but all comparisons indicated that BMI was at least as strongly related to adverse risk factor levels as was the sum of subscapular and triceps skinfold thicknesses (SF sum). For example, adjusted cross-sectional associations with the risk factor summary were r = 0.55 (BMI) and r = 0.49 (SF sum), p < 0.001 for difference between correlations. Similar differences were seen in longitudinal analyses, with changes in the risk factor summary being more strongly associated with changes in BMI (r =0.50) than with changes in the SF sum (r = 0.38).
BMI appears to be at least as accurate as skinfold thicknesses in identifying metabolic risk among adults. The advantages of BMI should be considered in the design and interpretation of clinical and epidemiologic studies.
虽然心血管疾病风险因素的不良水平与成年人的皮褶厚度和体重指数（BMI）相关，但这些关联的相对强度尚不清楚。我们研究肱三头肌和肩胛下皮褶厚度与成年人血脂、空腹胰岛素和血压水平的相关性是否比BMI更强。
对1983年至2002年在博加卢萨心脏研究中检查的18至44岁人群进行横断面分析（n = 3318）和纵向分析（n = 1593）。采用主成分分析得出六个检查的风险因素（甘油三酯、低密度和高密度脂蛋白胆固醇、胰岛素以及收缩压和舒张压）的综合指数。
差异幅度通常较小，但所有比较均表明，BMI与不良风险因素水平的相关性至少与肩胛下和肱三头肌皮褶厚度之和（皮褶厚度总和）一样强。例如，与风险因素综合指数的调整后横断面关联为r = 0.55（BMI）和r = 0.49（皮褶厚度总和），相关性差异p < 0.001。纵向分析中也观察到类似差异，风险因素综合指数的变化与BMI变化（r = 0.50）的相关性比与皮褶厚度总和变化（r = 0.38）更强。
在识别成年人的代谢风险方面，BMI似乎至少与皮褶厚度一样准确。在临床和流行病学研究的设计和解释中应考虑BMI的优势。
