Sellon R K, Menard M M, Meuten D J, Lengerich E J, Steurer F J, Breitschwerdt E B
Department of Companion Animal and Special Species Medicine, North Carolina State University, College of Veterinary Medicine, Raleigh 27606.
J Vet Intern Med. 1993 Jan-Feb;7(1):16-9. doi: 10.1111/j.1939-1676.1993.tb03163.x.
Visceral leishmaniasis was diagnosed by cytology and positive indirect immunofluorescent antibody titers to Leishmania donovani in a 7-month-old female Basenji dog from Texas. Clinical and laboratory findings included weight loss, hematochezia, hyperglobulinemia, hypoalbuminemia, anemia, and neutrophilic leukocytosis. Evidence of response to treatment with diminazene aceturate and ketoconazole included improvement in the abnormal clinical, hematologic, and biochemical findings, decreased serum globulin concentration and antibody titer to Leishmania donovani, and absence of organisms in examined tissues. Several foci of endemic leishmaniasis have been reported in the United States. Because of its zoonotic potential and the lack of approved treatments for dogs with leishmaniasis in the United States, the development of effective treatment strategies is needed.
一只来自得克萨斯州的7个月大雌性巴仙吉犬经细胞学检查及杜氏利什曼原虫间接免疫荧光抗体滴度呈阳性，被诊断为内脏利什曼病。临床和实验室检查结果包括体重减轻、便血、球蛋白血症、低白蛋白血症、贫血和嗜中性白细胞增多。使用乙酰甘氨酸二脒那嗪和酮康唑治疗有反应的证据包括异常临床、血液学和生化检查结果有所改善，血清球蛋白浓度和杜氏利什曼原虫抗体滴度降低，以及在检查的组织中未发现病原体。在美国已报告了几个内脏利什曼病的地方性病灶。鉴于其具有人畜共患病的可能性，且美国缺乏针对患利什曼病犬的获批治疗方法，因此需要制定有效的治疗策略。
