Robins-Browne R M, Yam W C, O'Gorman L E, Bettelheim K A
Department of Microbiology, Royal Children's Hospital, Parkville, Victoria, Australia.
J Med Microbiol. 1993 Mar;38(3):222-6. doi: 10.1099/00222615-38-3-222.
Nine strains of Escherichia coli isolated from infants with diarrhoea between 1947 and 1960 and designated "enteropathogenic" were examined for phenotypic and genetic characters associated with virulence. Each strain belonged to a different serotype. All the isolates were historically significant in that they were amongst the first strains of E. coli reported to be causally associated with infantile diarrhoea. Five strains possessed the virulence properties of class I enteropathogenic E. coli (EPEC). All these strains were isolated originally from symptomatic children during outbreaks of diarrhoea. Two isolates from sporadic cases of diarrhoea fulfilled the criteria for classification as class II EPEC. One strain was identified as enteroaggregative E. coli and the other carried no known virulence-associated properties. These findings indicate that most early isolates of E. coli which were designated "enteropathogenic" were indeed EPEC, as currently defined.
对1947年至1960年间从腹泻婴儿中分离出的、被指定为“肠致病性”的9株大肠杆菌进行了与毒力相关的表型和遗传特征检测。每株菌属于不同的血清型。所有分离株都具有历史意义，因为它们是最早报道的与婴儿腹泻有因果关系的大肠杆菌菌株。5株菌具有I类肠致病性大肠杆菌（EPEC）的毒力特性。所有这些菌株最初都是在腹泻暴发期间从有症状的儿童中分离出来的。两株从散发性腹泻病例中分离出的菌株符合II类EPEC的分类标准。一株被鉴定为肠聚集性大肠杆菌，另一株未携带已知的与毒力相关的特性。这些发现表明，大多数早期被指定为“肠致病性”的大肠杆菌分离株确实是目前所定义的EPEC。
