Arfken C L, Schulman P, McLaren M J, Lachman A S
Yale University, New Haven, Connecticut.
Pediatr Cardiol. 1993 Jan;14(1):33-6. doi: 10.1007/BF00794842.
Mitral valve prolapse has generally been associated in adults with a thin body habitus. However, prior studies used biased samples or limited anthropometric measures. In addition, no information has been available on the subjective assessment of body habitus and diagnosis of mitral valve prolapse, especially in children. We conducted a cross-sectional study on 813 children with uniform assessment of anthropometric measures and mitral valve prolapse. Consistent with research conducted on adults, those subjects with mitral valve prolapse were lighter, thinner, and had, on average, lower values for several, quantifiable anthropometric parameters with the exception of height. However, the subjective assessment showed that while the assessment did not differ by diagnosis, those subjects with mitral valve prolapse were never described as fat. These data support an association between mitral valve prolapse and slender body habitus and extends it to children, thus underscoring the clinical importance that a thin body habitus may be a marker for mitral valve prolapse throughout the age span. This association may partly explain the observed genetic distribution of mitral valve prolapse.
二尖瓣脱垂在成年人中通常与体型消瘦有关。然而，既往研究使用的样本存在偏差或人体测量指标有限。此外，关于体型的主观评估以及二尖瓣脱垂的诊断，尤其是在儿童中，尚无相关信息。我们对813名儿童进行了一项横断面研究，对人体测量指标和二尖瓣脱垂进行了统一评估。与针对成年人的研究一致，那些患有二尖瓣脱垂的受试者体重更轻、体型更瘦，除身高外，几个可量化的人体测量参数的平均值也更低。然而，主观评估显示，虽然评估结果不因诊断而异，但患有二尖瓣脱垂的受试者从未被描述为肥胖。这些数据支持二尖瓣脱垂与苗条体型之间的关联，并将其扩展至儿童，从而强调了苗条体型可能是全年龄段二尖瓣脱垂标志的临床重要性。这种关联可能部分解释了观察到的二尖瓣脱垂的遗传分布情况。
