Jibiki I, Matsuda H, Kido H, Kurokawa K, Yamaguchi N, Hisada K
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Acta Neurol (Napoli). 1993 Feb;15(1):7-15.
Quantitative assessment of regional cerebral blood flow (rCBF) in the bilateral cerebral and cerebellar cortices was performed in 22 normal adult subjects consisting of an early twenties group (5 men and 9 women, 20-22 years) and middle age group (3 men and 5 women, 41-52 years), using single photon emission computed tomography (SPECT) with N-isopropyl-(iodine 123) p-iodoamphetamine. Absolute rCBF values in each region in the 22 subjects ranged from 46 to 102 ml/100 g/min (mean 69.1, standard deviation 13.7 ml/100 g/min). The absolute rCBF values were significantly higher in women than in men, and in the early twenties group than in the middle age group. In addition, based on each absolute rCBF value, the interhemispheric asymmetry, anterior to posterior ratio and cerebellar to frontal ratio in rCBF were calculated. These results may be useful as indexes for detecting organic and functional brain abnormalities in various neuropsychiatric diseases.
使用单光子发射计算机断层扫描（SPECT）和N-异丙基-（碘123）对碘安非他明，对22名正常成年受试者的双侧大脑皮质和小脑皮质进行了局部脑血流量（rCBF）的定量评估。这22名受试者包括一个二十出头的组（5名男性和9名女性，20 - 22岁）和一个中年组（3名男性和5名女性，41 - 52岁）。22名受试者各区域的绝对rCBF值范围为46至102毫升/100克/分钟（平均69.1，标准差13.7毫升/100克/分钟）。女性的绝对rCBF值显著高于男性，二十出头组的绝对rCBF值显著高于中年组。此外，根据每个绝对rCBF值，计算了rCBF的半球间不对称性、前后比和小脑与额叶比。这些结果可能作为检测各种神经精神疾病中器质性和功能性脑异常的指标。
