转化生长因子-β在体内是否对关节软骨有保护作用？
Does TGF-beta protect articular cartilage in vivo?
作者信息
van Beuningen H M, van der Kraan P M, Arntz O J, van den Berg W B
机构信息
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
出版信息
Agents Actions Suppl. 1993;39:127-31. doi: 10.1007/978-3-0348-7442-7_14.
PMID:8456624
Abstract
Repeated intraarticular injections of transforming growth factor beta cause stimulation of articular cartilage proteoglycan synthesis, influx of inflammatory cells, fibrosis and osteophyte formation. When injected together with interleukin-1, TGF-beta enhances IL-1 induced cell-attraction in a synergistic way, while it counteracts IL-1 induced suppression of cartilage PG synthesis.
摘要
反复关节内注射转化生长因子β会导致关节软骨蛋白聚糖合成受刺激、炎症细胞流入、纤维化和骨赘形成。当与白细胞介素-1一起注射时，转化生长因子β以协同方式增强白细胞介素-1诱导的细胞吸引作用，同时抵消白细胞介素-1诱导的软骨蛋白聚糖合成抑制作用。
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