Ratcliffe A, Beauvais P J, Saed-Nejad F, Shurety W, Caterson B
Orthopaedic Research Laboratory, Columbia University, New York, NY 10032.
Agents Actions Suppl. 1993;39:63-7. doi: 10.1007/978-3-0348-7442-7_5.
Canine experimental models of osteoarthritis (OA) and disuse atrophy were used to study cartilage metabolism. The synovial fluids from the OA joints showed elevated levels of keratan sulfate (KS) epitope and link protein, indicating increased catabolism. Analysis of fluids from joints with disuse atrophy showed high levels of KS epitope, but no increase in link protein. Quantitation of a novel chondroitin sulfate (3B3) epitope showed it to be present only in the synovial fluids and articular cartilage of the OA joints. The results indicate that these may be important indicators, or markers, of degenerative joint disease.
采用犬骨关节炎（OA）和废用性萎缩实验模型来研究软骨代谢。OA关节的滑液中硫酸角质素（KS）表位和连接蛋白水平升高，表明分解代谢增加。对废用性萎缩关节的滑液分析显示KS表位水平较高，但连接蛋白没有增加。一种新型硫酸软骨素（3B3）表位的定量分析表明，它仅存在于OA关节的滑液和关节软骨中。结果表明，这些可能是退行性关节疾病的重要指标或标志物。
