Antonini A, Leenders K L, Meier D, Oertel W H, Boesiger P, Anliker M
PET Department, Paul Scherrer Institute, Villigen, Switzerland.
Neurology. 1993 Apr;43(4):697-700. doi: 10.1212/wnl.43.4.697.
Postmortem studies of patients with Parkinson's disease (PD) reveal an increase in iron concentration in the substantia nigra. Iron content in the brain is associated with decreased signal intensity on T2-weighted MRI. We measured in vivo the T2 relaxation time in 30 PD patients and 33 healthy volunteer subjects, using a 1.5-T whole-body MRI system. In comparison with healthy controls, T2 values in PD patients were reduced in the following brain regions: substantia nigra, caudate nucleus, and putamen. Due to the overlap between patients and control subjects, we could not differentiate, in a given patient, healthy from diseased state on the basis of T2 relaxation time. Our findings support the notion of increased iron deposition in the substantia nigra of patients with PD. However, the shortening of T2 values in the substantia nigra did not correlate with disease duration nor with clinical severity.
帕金森病（PD）患者的尸检研究显示黑质中铁浓度增加。大脑中的铁含量与T2加权磁共振成像（MRI）上信号强度降低有关。我们使用1.5-T全身MRI系统对30例PD患者和33名健康志愿者进行了体内T2弛豫时间测量。与健康对照组相比，PD患者在以下脑区的T2值降低：黑质、尾状核和壳核。由于患者和对照受试者之间存在重叠，我们无法根据T2弛豫时间在特定患者中区分健康状态和患病状态。我们的研究结果支持PD患者黑质中铁沉积增加的观点。然而，黑质中T2值的缩短与疾病持续时间或临床严重程度均无相关性。
